All Phenotypes Mmp8<tm1Otin> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mmp8^tm1Otin
targeted mutation 1, Carlos Lopez-Otin
MGI:2681103

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp8^tm1Otin/Mmp8^tm1Otin	involves: 129X1/SvJ	MGI:4367713
hm2	Mmp8^tm1Otin/Mmp8^tm1Otin	involves: 129X1/SvJ * C57BL/6	MGI:3785290
hm3	Mmp8^tm1Otin/Mmp8^tm1Otin	involves: 129X1/SvJ * C57BL/6J	MGI:2681109
cx4	Mmp8^tm1Otin/Mmp8^tm1Otin Mmp9^tm1Tvu/Mmp9^tm1Tvu	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:3785292

Allelic Composition	Mmp8^tm1Otin/Mmp8^tm1Otin
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8^tm1Otin mutation (1 available); any Mmp8 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:148442 )

N	• mice exhibit normal response to Coxsackievirus B3 (CVB3) infection

Allelic Composition	Mmp8^tm1Otin/Mmp8^tm1Otin
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8^tm1Otin mutation (1 available); any Mmp8 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:113463 )

N	• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis

Allelic Composition	Mmp8^tm1Otin/Mmp8^tm1Otin
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8^tm1Otin mutation (1 available); any Mmp8 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:86393 )

• succeptibility to tumor induction significantly greater in males than in females and latency is shorter

• ovarectomy or tamoxifen treatment increased skin cancer incidence in females

• rate of progression from benign to malignant was normal

increased fibrosarcoma incidence ( J:86393 )

• formed in response to intradermal injection of methylcholanthrene

• all were invasive tumors

increased papilloma incidence ( J:86393 )

• formed in response to DMBA+TPA

immune system

abnormal inflammatory response ( J:86393 )

• inflammatory response slower to establish itself

chronic inflammation ( J:86393 )

• sustained inflammatory response to injected carcinogens develops

• accumulated cells were neutrophils

increased susceptibility to bacterial infection ( J:97118 )

• intratracheal lipopolysaccharide (LPS) treatment results in 2 fold increase in polymorphonuclear cell accumulation in the alveolar space and approximately 3 fold increase in myeloperoxidase activity in bronchioalveolar lavage lysate

Allelic Composition	Mmp8^tm1Otin/Mmp8^tm1Otin Mmp9^tm1Tvu/Mmp9^tm1Tvu
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8^tm1Otin mutation (1 available); any Mmp8 mutation (27 available)
Mmp9^tm1Tvu mutation (2 available); any Mmp9 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:113463 )

N	• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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