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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mmp8tm1Otin
targeted mutation 1, Carlos Lopez-Otin
MGI:2681103
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mmp8tm1Otin/Mmp8tm1Otin involves: 129X1/SvJ MGI:4367713
hm2
Mmp8tm1Otin/Mmp8tm1Otin involves: 129X1/SvJ * C57BL/6 MGI:3785290
hm3
Mmp8tm1Otin/Mmp8tm1Otin involves: 129X1/SvJ * C57BL/6J MGI:2681109
cx4
Mmp8tm1Otin/Mmp8tm1Otin
Mmp9tm1Tvu/Mmp9tm1Tvu
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:3785292


Genotype
MGI:4367713
hm1
Allelic
Composition
Mmp8tm1Otin/Mmp8tm1Otin
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal response to Coxsackievirus B3 (CVB3) infection




Genotype
MGI:3785290
hm2
Allelic
Composition
Mmp8tm1Otin/Mmp8tm1Otin
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis




Genotype
MGI:2681109
hm3
Allelic
Composition
Mmp8tm1Otin/Mmp8tm1Otin
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• succeptibility to tumor induction significantly greater in males than in females and latency is shorter
• ovarectomy or tamoxifen treatment increased skin cancer incidence in females
• rate of progression from benign to malignant was normal
• formed in response to intradermal injection of methylcholanthrene
• all were invasive tumors
• formed in response to DMBA+TPA

immune system
• inflammatory response slower to establish itself
• sustained inflammatory response to injected carcinogens develops
• accumulated cells were neutrophils
• intratracheal lipopolysaccharide (LPS) treatment results in 2 fold increase in polymorphonuclear cell accumulation in the alveolar space and approximately 3 fold increase in myeloperoxidase activity in bronchioalveolar lavage lysate




Genotype
MGI:3785292
cx4
Allelic
Composition
Mmp8tm1Otin/Mmp8tm1Otin
Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp8tm1Otin mutation (1 available); any Mmp8 mutation (17 available)
Mmp9tm1Tvu mutation (2 available); any Mmp9 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory