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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdk5r1tm1Ohsh
targeted mutation 1, Toshio Ohshima
MGI:2680652
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh involves: 129 * C57BL/6J MGI:3719575
hm2
Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh Not Specified MGI:3719564


Genotype
MGI:3719575
hm1
Allelic
Composition
Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm1Ohsh mutation (0 available); any Cdk5r1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a Morris maze test with hidden platform, spatial learning and memory are impaired
• at 3 months of age, males show a significantly impaired ability to maintain balance on a rotating rod at two different speeds (5 and 10 rpm)
• however, grip strength is normal in a traction test, indicating that poor rotarod performance is not due to muscle weakness

nervous system
• granule cells are dispersed in the dentate gyrus
• CA3 pyramidal neurons are disorganized
• long term depression in response to low-frequency stimulation is only transiently decreased and returns to baseline within 10 to 15 minutes whereas depression is long-term in wild-type mice
• following stimulation with tetanus, depotentiation is impaired




Genotype
MGI:3719564
hm2
Allelic
Composition
Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm1Ohsh mutation (0 available); any Cdk5r1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a 2-fold or greater increase in withdrawal latency time

integument
• mice exhibit a 2-fold or greater increase in withdrawal latency time





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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory