About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nod2tm1Pmu
targeted mutation 1, Peter J Murray
MGI:2680581
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nod2tm1Pmu/Nod2tm1Pmu involves: BALB/c * C57BL/6 MGI:2680589


Genotype
MGI:2680589
hm1
Allelic
Composition		 Nod2tm1Pmu/Nod2tm1Pmu
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nod2tm1Pmu mutation (0 available); any Nod2 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:86264 )
• normal response to most activating and deactivating stimuli
• failure to respond to muramyl dipeptide stimulation
• no Il12 secretion
decreased susceptibility to endotoxin shock ( J:86264 )
• enhanced survival of endotoxic shock from higher doses of bacterial lipopolysaccharide under some conditions

hematopoietic system
abnormal macrophage physiology ( J:86264 )
• normal response to most activating and deactivating stimuli
• failure to respond to muramyl dipeptide stimulation
• no Il12 secretion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory