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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpe65450M
450 Methionine
MGI:2680347
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rpe65450M/Rpe65450M C57BL/6J-Tyrc-2J MGI:2680428
cx2
 		Rpe65450M/Rpe65450M
Rpgrtm1Wbrg/Rpgrtm1Wbrg 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:4458095
cx3
 		Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947236


Genotype
MGI:2680428
hm1
Allelic
Composition		 Rpe65450M/Rpe65450M
Genetic
Background		 C57BL/6J-Tyrc-2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpe65450M mutation (0 available); any Rpe65 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:86186 )
• decreased rod photoreceptor gain relative to BALB/cByJ
• increased latency to recovery from photobleach relative to BALB/cByJ




Genotype
MGI:4458095
cx2
Allelic
Composition		 Rpe65450M/Rpe65450M
Rpgrtm1Wbrg/Rpgrtm1Wbrg
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpe65450M mutation (0 available); any Rpe65 mutation (48 available)
Rpgrtm1Wbrg mutation (0 available); any Rpgr mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:160802 )
• authors state that mice exhibit the same eye phenotype as observed when mice are backcrossed to BALB/c for 8 generations
abnormal eye physiology ( J:160802 )
• authors state that mice exhibit the same eye phenotype as observed when mice are backcrossed to BALB/c for 8 generations




Genotype
MGI:4947236
cx3
Allelic
Composition		 Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrattm1Kpal mutation (1 available); any Lrat mutation (26 available)
Rhotm1.1Kpal mutation (1 available); any Rho mutation (48 available)
Rpe65450L mutation (1 available); any Rpe65 mutation (48 available)
Rpe65450M mutation (0 available); any Rpe65 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Effect of genetic depletion of 11-cis-retinal production (Lrattm1Kpal/Lrattm1Kpal) on retinal degeneration in Rhotm1.1Kpal/Rho+ mice

vision/eye
decreased retina photoreceptor cell number ( J:170648 )
• dramatically reduced at P36
abnormal retina rod cell outer segment morphology ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes
retina photoreceptor degeneration ( J:170648 )
• due to increased apoptosis
retina rod cell degeneration ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes

nervous system
decreased retina photoreceptor cell number ( J:170648 )
• dramatically reduced at P36
abnormal retina rod cell outer segment morphology ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes
retina photoreceptor degeneration ( J:170648 )
• due to increased apoptosis
retina rod cell degeneration ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory