All Phenotypes Mapkapk5<tm1Mgl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapkapk5^tm1Mgl
targeted mutation 1, Matthias Gaestel
MGI:2680287

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapkapk5^tm1Mgl/Mapkapk5^tm1Mgl	involves: 129P2/OlaHsd * C57BL/6	MGI:2680292

Allelic Composition	Mapkapk5^tm1Mgl/Mapkapk5^tm1Mgl
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5^tm1Mgl mutation (0 available); any Mapkapk5 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:86268 )

• homozygotes are viable, fertile, and behaviorally normal, with no apparent abnormalities in heart, skeletal and pancreas tissue morphology relative to wild-type littermates

• unlike Mapkapk2^tm1Mgl mutant mice, homozygotes do not exhibit increased resistance to endotoxic shock or decreased LPS-induced biosynthesis of TNF, IL-6, or IFN-gamma in spleen cells but display the same susceptibility to LPS-mediated liver failure as wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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