Phenotypes associated with this allele

• Allele Symbol: Nr1h4^tm1Kok
• Allele Name: targeted mutation 1, Tineke Kok
• Allele ID: MGI:2679472
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1h4^tm1Kok/Nr1h4^tm1Kok	involves: 129P2/OlaHsd * C57BL/6J	MGI:2679498

Genotype
MGI:2679498

hm1

• Allelic Composition: Nr1h4^tm1Kok/Nr1h4^tm1Kok
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:86154 )

• mildly elevated plasma bile salt concentrations

abnormal bile salt homeostasis ( J:86154 )

• 39% increase in total bile salt pool relative to control

• 67% increase in cholate pool size due to approximately 2-fold increase in intestinal reabsorption relative to wild-type

• cholate synthesis rate is increased by 2-fold, however fractional turnover rate and cycling time of cholate pool are normal

• fecal loss of bile salts is increased by about 70%

increased bile salt level ( J:86154 )

• mildly elevated plasma bile salt concentrations

• total bile salt pool size is increased by 39%

liver/biliary system

abnormal bile secretion ( J:86154 )

• bile formation process itself does not appear to be affected, however a higher bile flow rate is caused by a 2.4-fold increase in the biliary output rate of bile salts

abnormal bile composition ( J:86154 )

• biliary bile salt concentration in the bile is increased