Phenotypes associated with this allele

• Allele Symbol: Prkca^tm1Far
• Allele Name: targeted mutation 1, Bob Farese
• Allele ID: MGI:2679305
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkca^tm1Far/Prkca^tm1Far	involves: 129/Sv * 129P2/OlaHsd	MGI:2679313
hm2	Prkca^tm1Far/Prkca^tm1Far	involves: 129P2/OlaHsd	MGI:4821151

Genotype
MGI:2679313

hm1

• Allelic Composition: Prkca^tm1Far/Prkca^tm1Far
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased adipocyte glucose uptake ( J:85923 )

• isolated adipocytes show a 67% increase in insulin-stimulated 2-deoxyglucose uptake, but normal levels of basal uptake

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:85923 )

N • fed mice show normal serum glucose and insulin levels

abnormal enzyme/coenzyme activity ( J:85923 )

• vastus lateralis muscles show increased insulin-induced enzyme activities of IRS1 dependent PI3K (PIK3), PKB (AKT), PKClambda (PRKCI), and ERK (EPHB2), but normal basal levels

muscle

increased muscle cell glucose uptake ( J:85923 )

• soleus muscles show a 108% increase in insulin-stimulated 2-deoxyglucose uptake, but normal levels of basal uptake

cellular

increased adipocyte glucose uptake ( J:85923 )

• isolated adipocytes show a 67% increase in insulin-stimulated 2-deoxyglucose uptake, but normal levels of basal uptake

increased muscle cell glucose uptake ( J:85923 )

• soleus muscles show a 108% increase in insulin-stimulated 2-deoxyglucose uptake, but normal levels of basal uptake

Genotype
MGI:4821151

hm2

• Allelic Composition: Prkca^tm1Far/Prkca^tm1Far
• Genetic Background: involves: 129P2/OlaHsd

nervous system

nervous system phenotype ( J:159855 )

N • CCK-8-treated mice exhibit a normal increase in AMPA excitatory postsynaptic currents