About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sftpdtm2Haw
targeted mutation 2, Samuel Hawgood
MGI:2677969
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Sftpa1tm2Haw/Sftpa1tm2Haw
Sftpdtm2Haw/Sftpdtm2Haw
involves: C57BL/6J * CD-1 MGI:2677992


Genotype
MGI:2677992
cx1
Allelic
Composition
Sftpa1tm2Haw/Sftpa1tm2Haw
Sftpdtm2Haw/Sftpdtm2Haw
Genetic
Background
involves: C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpa1tm2Haw mutation (1 available); any Sftpa1 mutation (22 available)
Sftpdtm2Haw mutation (1 available); any Sftpd mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased macrophages in bronchoalveolar lavage fluid by week 6, dramatically increased at week 16
• patchy subpleural areas with abnormal macrophage accumulations, becoming very extensive by week 16
• alveolar macrophages grossly enlarged by week 16

immune system
• increased macrophages in bronchoalveolar lavage fluid by week 6, dramatically increased at week 16
• patchy subpleural areas with abnormal macrophage accumulations, becoming very extensive by week 16
• alveolar macrophages grossly enlarged by week 16

respiratory system
• progressive accumulation of phospholipids and protein in bronchoalveolar lavage fluid, significantly greater than in wild-type mice by week 6
• by week 16 accumulation of airspace secretions at significant levels
• alveolar macrophages grossly enlarged by week 16
• abnormal cellular accumulations arising from alveoli and extending into the alveolar space by week 16
• enlarged air spaces and considerable size variability
• epithelial surface area decreased indicating a loss of gas exchange surface per unit volume
• septal thickening by week 16

homeostasis/metabolism
• progressive accumulation of phospholipids in broncheolar lavage fluid is seen





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory