About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTB-cre)1Tes
transgene insertion 1, Lino Tessarollo
MGI:2677702
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Vhltm1Lss/Vhltm1.1Lss
Tg(ACTB-cre)1Tes/0
involves: 129X1/SvJ * C3H * C57BL/6 MGI:2677759


Genotype
MGI:2677759
cn1
Allelic
Composition
Vhltm1Lss/Vhltm1.1Lss
Tg(ACTB-cre)1Tes/0
Genetic
Background
involves: 129X1/SvJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-cre)1Tes mutation (0 available)
Vhltm1.1Lss mutation (0 available); any Vhl mutation (6 available)
Vhltm1Lss mutation (0 available); any Vhl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• abnormal sperm maturation with multinucleated giant cells
• 30-fold reduction in sperm count relative to wild-type

mortality/aging
• mice began to die after 3 months of age
• 50% mortalitiy exhibited by 7 months of age
• 90% mortalitiy by 1 year of age

neoplasm
• all mice displayed grossly visible hemangiomas by 1 year of age

cardiovascular system
• frequent angiectasis in the liver and with lesser penetrance in the kidneys
• increased vasculature of the pancreas
• no vascular lesions observed in the brain, ovary, or adrenal glands
• limited new blood vessel formation in the liver
• angiogenesis observed the cardiac muscle of 8 of 10 mice examined

endocrine/exocrine glands
• enlarged blood vessels in the connective tissue surrounding the tubules
• tubule atrophy and collapse

liver/biliary system
• livers were irregularly shaped and had vascular lesions containing large, thin-walled vessels filled with blood
• all mice displayed grossly visible hemangiomas by 1 year of age

reproductive system
• abnormal sperm maturation with multinucleated giant cells
• 30-fold reduction in sperm count relative to wild-type
• enlarged blood vessels in the connective tissue surrounding the tubules
• tubule atrophy and collapse

Mouse Models of Human Disease
OMIM ID Ref(s)
Von Hippel-Lindau Syndrome; VHL 193300 J:85513





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory