mortality/aging
|
• mice began to die after 3 months of age
• 50% mortalitiy exhibited by 7 months of age
• 90% mortalitiy by 1 year of age
|
tumorigenesis
|
• all mice displayed grossly visible hemangiomas by 1 year of age
|
cardiovascular system
|
• frequent angiectasis in the liver and with lesser penetrance in the kidneys
• increased vasculature of the pancreas
• no vascular lesions observed in the brain, ovary, or adrenal glands
|
|
• limited new blood vessel formation in the liver
• angiogenesis observed the cardiac muscle of 8 of 10 mice examined
|
endocrine/exocrine glands
 |
• enlarged blood vessels in the connective tissue surrounding the tubules
(J:85513)
• tubule atrophy and collapse
(J:85513)
|
|
|
(J:85513)
|
small testis
(
J:85513
)
|
|
(J:85513)
|
liver/biliary system
|
• livers were irregularly shaped and had vascular lesions containing large, thin-walled vessels filled with blood
|
reproductive system
|
|
• enlarged blood vessels in the connective tissue surrounding the tubules
(J:85513)
• tubule atrophy and collapse
(J:85513)
|
|
|
(J:85513)
|
small testis
(
J:85513
)
|
|
(J:85513)
|
|
|
• abnormal sperm maturation with multinucleated giant cells
(J:85513)
|
|
|
• 30-fold reduction in sperm count relative to wild-type
(J:85513)
|
|
|
(J:85513)
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Von Hippel-Lindau Syndrome; VHL | 193300 | J:85513 | |