About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb1tm1Cmn
targeted mutation 1, Carol A Mason
MGI:2677305
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb1tm1Cmn/Ephb1tm1Cmn involves: 129S1/Sv * 129X1/SvJ MGI:5306419
hm2
 		Ephb1tm1Cmn/Ephb1tm1Cmn involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2677319
ht3
 		Ephb1tm1Cmn/Ephb1+ involves: 129S1/Sv * 129X1/SvJ MGI:5306418
ht4
 		Ephb1tm1Cmn/Ephb1tm2Cmn involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2677322
cx5
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129/Sv * CD-1 MGI:2677321
cx6
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5306604
cx7
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:5306605
cx8
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5306606
cx9
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2tm2Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:5306607
cx10
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3851502
cx11
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3851503


Genotype
MGI:5306419
hm1
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:2677319
hm2
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal optic tract morphology ( J:85573 )
• marked reduction of the ipsilateral optic tract, by 43%, both at E17.5 and at birth
• axons from the ventrotemporal retina tend to cross the midline
• no obvious guidance errors in the optic nerve or tract other than ipsilateral reduction
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

vision/eye
vision/eye phenotype ( J:85573 )
N
• no intraretinal axon guidance errors observed in E17.5 embryos

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




Genotype
MGI:5306418
ht3
Allelic
Composition		 Ephb1tm1Cmn/Ephb1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:2677322
ht4
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm2Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:85573 )
• express beta-gal in cells normally expressing Ephb1
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally

nervous system
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally




Genotype
MGI:2677321
cx5
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (66 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye

nervous system
abnormal optic tract morphology ( J:85573 )
• axons from ventrotemporal retina tend to cross the midline




Genotype
MGI:5306604
cx6
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306605
cx7
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306606
cx8
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm2Paw mutation (0 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306607
cx9
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2tm2Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm2Paw mutation (0 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:3851502
cx10
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




Genotype
MGI:3851503
cx11
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (42 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (66 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory