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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pkd2tm1Dwo
targeted mutation 1, Bernd Dworniczak
MGI:2676373
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pkd2tm1Dwo/Pkd2tm1Dwo either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:2676553


Genotype
MGI:2676553
hm1
Allelic
Composition
Pkd2tm1Dwo/Pkd2tm1Dwo
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2tm1Dwo mutation (1 available); any Pkd2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• defects affecting septation, the outflow tract, trabecularization, and the formation of the myocardial wall
• focal hemorrhages after E13.5

embryo
• randomization of embryonic turning
• multiple laterality defects

endocrine/exocrine glands
• abnormally positioned on the right side of the abdomen in most embyros
• fluid-filled cysts in both ventral and dosal pancreatic lobes

growth/size/body
• most embyros exhibited an inversion of abdominal situs with a right sided stomach and pancreas

hematopoietic system
• the spleen was absent or severely reduced in size

homeostasis/metabolism
• progressive whole-body edema developed after E13.5

immune system
• the spleen was absent or severely reduced in size

liver/biliary system
• frequently showed abnormal lobation and/or midline positioning

renal/urinary system
• first apparent around E15
• predominantly glomerular cysts

respiratory system
• with 4 lobes on each side in contrast to the asymmetric lobulation observed in wild-type
• 6% showed normal lobulation

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 2; PKD2 613095 J:77401





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory