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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syn3tm1Pggd
targeted mutation 1, Paul Greengard
MGI:2675750
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Syn3tm1Pggd/Syn3tm1Pggd B6.129X1-Syn3tm1Jfe MGI:5517485
hm2
Syn3tm1Pggd/Syn3tm1Pggd involves: 129X1/SvJ MGI:2675753
cx3
Syn1tm1Pggd/Syn1tm1Pggd
Syn2tm1Pggd/Syn2tm1Pggd
Syn3tm1Pggd/Syn3tm1Pggd
involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:5698534


Genotype
MGI:5517485
hm1
Allelic
Composition
Syn3tm1Pggd/Syn3tm1Pggd
Genetic
Background
B6.129X1-Syn3tm1Jfe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn3tm1Pggd mutation (2 available); any Syn3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the social transmission of food preference task, mutants show an absence of preference for the cued food over the novel food after one hour after social interaction with the demonstrator cagemate
• in the social dominance tube test, adults show more submissive behavior than controls
• in the social novelty test, young mutants do not discriminate between familiar and novel mice compared to controls that spend more time exploring the novel mouse than a familiar mouse indicating altered social novelty preference
• in the resident-intruder test, mutants show reduced social interaction with the intruder mice after 1-2 months of social isolation
• however, mutants exhibit normal anxiety related behaviors

taste/olfaction
N
• olfaction is intact

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:201707




Genotype
MGI:2675753
hm2
Allelic
Composition
Syn3tm1Pggd/Syn3tm1Pggd
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn3tm1Pggd mutation (2 available); any Syn3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• observed in hippocampal neurons in culture
• a slightly larger amplitude was noted
• a reduction in amplitude was noted
• reduced transmission noted after a 5 second stimulation in homozygotes
• time constants for depression range is increased two fold

cellular
• observed in hippocampal neurons in culture




Genotype
MGI:5698534
cx3
Allelic
Composition
Syn1tm1Pggd/Syn1tm1Pggd
Syn2tm1Pggd/Syn2tm1Pggd
Syn3tm1Pggd/Syn3tm1Pggd
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Pggd mutation (2 available); any Syn1 mutation (22 available)
Syn2tm1Pggd mutation (2 available); any Syn2 mutation (16 available)
Syn3tm1Pggd mutation (2 available); any Syn3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• opening of the home cage of adult mutants induces generalized tonic-clonic seizures that correlate with high amplitude and high frequency generalized synchronized activity followed by post-ictal depression in the theta frequency rage (3-6 Hz)
• seizures commence within seconds of cage opening and include vocalization, freezing, tail stiffing, back arching, bilateral limb movements, and loss of posture, followed by stereotypical grooming behavior
• the symptomatic seizure state is characterized by resistance to the epileptiform-promoting effects of 4-aminopyridine, by hypersensitivity to blockage of GABA(A) receptors and by the emergence of unresponsiveness to NMDA receptor antagonism
• opening of the home cage of adult mutants induces generalized tonic-clonic seizures
• however, mice exhibit spontaneous seizures only vary rarely

nervous system
• opening of the home cage of adult mutants induces generalized tonic-clonic seizures that correlate with high amplitude and high frequency generalized synchronized activity followed by post-ictal depression in the theta frequency rage (3-6 Hz)
• seizures commence within seconds of cage opening and include vocalization, freezing, tail stiffing, back arching, bilateral limb movements, and loss of posture, followed by stereotypical grooming behavior
• the symptomatic seizure state is characterized by resistance to the epileptiform-promoting effects of 4-aminopyridine, by hypersensitivity to blockage of GABA(A) receptors and by the emergence of unresponsiveness to NMDA receptor antagonism
• opening of the home cage of adult mutants induces generalized tonic-clonic seizures
• however, mice exhibit spontaneous seizures only vary rarely
• EEG indicates an abrupt transition during early adulthood from a seizure-free presymptomatic latent state to a consistent symptomatic state of sensory-induced seizures
• EEG indicates that during the latent period, larger field responses are elicited in slices from mutants than in controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:175256





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory