All Phenotypes Bcl3<tm1Rie> MGI Mouse

abnormal dendritic cell number ( J:77049 )

• number of CD11b^-CD8^- dendritic cells is reduced in Peyer's patches

• number of CD11b⁺ dendritic cells is increased in the enlarged T-cell regions of Peyer's patches

increased plasmacytoid dendritic cell number ( J:77049 )

• lymphoid dendritic cells are considerably increased in the follicle-associated epithelium of Peyer's patches

• reduction of B cells in Peyer's patches

abnormal myeloid dendritic cell morphology ( J:77049 )

• myeloid dendritic cells have a disordered distribution in the subepithelial dome of Peyer's patches and form a closer network in the adjacent B-cell region

• number of CD11b+ dendritic cells is increased in the enlarged T-cell regions of Peyer's patches

abnormal follicular dendritic cell morphology ( J:77049 )

• follicular dendritic cells do not form the clusters typically found in germinal centers

abnormal Peyer's patch morphology ( J:77049 )

• lack a well-organized subepithelial dome (SED) region

• Peyer's patches mainly consist of T cells

abnormal Peyer's patch follicle morphology ( J:77049 )

• follicles lack a clear demarcation at E13.5

• defective follicular organization, with less identifiable B cells with no clear detectible follicular structures

• 2-3 fold increase of M cells in the follicle-associated epithelium (FAE)

• CD8⁺ T cells are increased in the follicle-associated epithelium (FAE)

abnormal Peyer's patch T cell area morphology ( J:77049 )

• increase in the extent of CD3⁺ T cell areas

• increase of CD8+ T cells in the T-cell area

abnormal Peyer's patch germinal center morphology ( J:77049 )

• complete lack of germinal centers with a mature follicular dentritic cell network

decreased Peyer's patch number ( J:77049 )

small Peyer's patches ( J:77049 )