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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-MAPT)183Gotz
transgene insertion 183, Jurgen Gotz
MGI:2672839
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz MGI:4412051
tg2
Tg(Thy1-MAPT)183Gotz/0 B6.Cg-Tg(Thy1-MAPT)183Gotz MGI:4412053


Genotype
MGI:4412051
cx1
Allelic
Composition
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age

behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
• in a novel arena at 2 and 12 months but not at 4 months

homeostasis/metabolism
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age




Genotype
MGI:4412053
tg2
Allelic
Composition
Tg(Thy1-MAPT)183Gotz/0
Genetic
Background
B6.Cg-Tg(Thy1-MAPT)183Gotz
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2, 4 and 12 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning half-way through the acquisition phase at 2 months compared with wild-type mice
• however, mice exhibit normal spatial learning by the end of the acquisition phase at 2, 4, and 12 months
• on at rotarod at 12 months

nervous system
• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory