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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alg10bnse5
neurological/sensory 5
MGI:2671810
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Alg10bnse5/Alg10bnse5 129S6.B6-Alg10bnse5 MGI:5581451
hm2
 		Alg10bnse5/Alg10bnse5 involves: C57BL/6J MGI:3027186


Genotype
MGI:5581451
hm1
Allelic
Composition		 Alg10bnse5/Alg10bnse5
Genetic
Background		 129S6.B6-Alg10bnse5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alg10bnse5 mutation (1 available); any Alg10b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Outer hair cells of the cochlea are abnormal in Alg10bnse5/Alg10bnse5 mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:209766 )
N
• endocochlear potential is normal
abnormal cochlear outer hair cell morphology ( J:209766 )
• severely; some with punctate pattern of prestin staining in cytosol
cochlear outer hair cell degeneration ( J:209766 )
• however, degeneration is rescued by transgene expression of the gene
increased or absent threshold for auditory brainstem response ( J:209766 )
• however, ABR threshold is partially rescued by transgene expression of the gene
absent distortion product otoacoustic emissions ( J:209766 )
• however, ABR threshold is partially rescued by transgene expression of the gene
deafness ( J:209766 )
• however, deafness is rescued by transgene expression of the gene

nervous system
abnormal cochlear outer hair cell morphology ( J:209766 )
• severely; some with punctate pattern of prestin staining in cytosol
cochlear outer hair cell degeneration ( J:209766 )
• however, degeneration is rescued by transgene expression of the gene

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
nonsyndromic deafness DOID:0050563 J:209766




Genotype
MGI:3027186
hm2
Allelic
Composition		 Alg10bnse5/Alg10bnse5
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alg10bnse5 mutation (1 available); any Alg10b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
deafness ( J:85113 )
• non-syndromic deafness




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory