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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ldlrap1tm1Her
targeted mutation 1, Joachim Herz
MGI:2670480
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ldlrap1tm1Her/Ldlrap1tm1Her involves: 129S6/SvEvTac MGI:2670516


Genotype
MGI:2670516
hm1
Allelic
Composition
Ldlrap1tm1Her/Ldlrap1tm1Her
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrap1tm1Her mutation (1 available); any Ldlrap1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• LDL clearance is slowed
• on a chow diet, plasma LDL levels were higher than those in wild-type mice but lower than those in Ldlrtm1Her homozygous mutant mice
• little LDL accumulation on a normal diet
• on high cholesterol diets most plasma cholesterol is LDL
• plasma cholesterol is only mildly elevated (83mg/dl) on a normal diet
• plasma triglycerides increase more on a "wetern" diet than in Ldlrtm1Her homozygous mutant mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive hypercholesterolemia DOID:0090105 OMIM:603813
J:84694





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory