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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Btrctm1Kin
targeted mutation 1, Kei-ichi Nakayama
MGI:2669949
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Btrctm1Kin/Btrctm1Kin involves: C57BL/6 MGI:2669950


Genotype
MGI:2669950
hm1
Allelic
Composition
Btrctm1Kin/Btrctm1Kin
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrctm1Kin mutation (0 available); any Btrc mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• in spite of the abnormal accumulation of beta-catenin there is no increase in the incidence of cancer after 16 months of observation

cellular
• size of MEFs is substantially larger than that of wild-type MEFs
• percentage of polyploid cells is increased in mutant MEF cultures
• MEFs grown in culture show an increase in frequency of apoptosis
• MEFs grown in culture exhibit a reduced rate of proliferation compared to wild-type MEFs

hematopoietic system
• rate of proliferation of lymphocytes in response to various stimulants is reduced

immune system
• rate of proliferation of lymphocytes in response to various stimulants is reduced





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory