Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation
(0 available);
any
Rad23a mutation
(12 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation
(0 available);
any
Rad23a mutation
(12 available)
Rad23btm1Gvh mutation
(0 available);
any
Rad23b mutation
(42 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation
(0 available);
any
Rad23a mutation
(12 available)
Rad23btm1Gvh mutation
(0 available);
any
Rad23b mutation
(42 available)
|
|
|
mortality/aging
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• however, cells are capable of nucleotide excision repair
• embryos survive at least through E13.5 when mouse embryo fibroblasts were isolated
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation
(0 available);
any
Rad23a mutation
(12 available)
Rad23btm1Gvh mutation
(0 available);
any
Rad23b mutation
(42 available)
|
|
|
mortality/aging
|
• embryos die sometime between E8.5 and E10.5
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cellular
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• embryos are deficient in nucleotide excision repair
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homeostasis/metabolism