Phenotypes associated with this allele

• Allele Symbol: Men1^tm1.1Zqw
• Allele Name: targeted mutation 1.1, Zhao-Qi Wang
• Allele ID: MGI:2664873
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Men1^tm1.1Zqw/Men1^tm1.1Zqw	involves: 129P2/OlaHsd * C57BL/6	MGI:2669265

Genotype
MGI:2669265

hm1

• Allelic Composition: Men1^tm1.1Zqw/Men1^tm1.1Zqw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:83882 )

• embryos start to die between E12.5 and 13.5; no homozygotes survived to E15.5

cellular

abnormal cell differentiation ( J:83882 )

• ES cell differentiation impaired; rescued by injection of menin cDNA

• homozygous ES cells showed very limited contribution to liver development in E18 chimeric embryos

• mutant ES cell proliferation is not affected

nervous system

abnormal neural tube closure ( J:83882 )

embryo

abnormal neural tube closure ( J:83882 )