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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkcqtm1.1Bai
targeted mutation 1.1, Gottfried Baier
MGI:2664377
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkcqtm1.1Bai/Prkcqtm1.1Bai involves: 129P2/OlaHsd * C57BL/6J MGI:2664378


Genotype
MGI:2664378
hm1
Allelic
Composition		 Prkcqtm1.1Bai/Prkcqtm1.1Bai
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcqtm1.1Bai mutation (0 available); any Prkcq mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:83733 )
• mature CD3+T cells fail to mobilize similar intracellular calcium levels compared to wild-type in response to CD3 crosslinking, however calcium responses stimulated by calcium-ionophore remain intact
• reduction in TCR-induced NFAT activation in T lymphocytes
• TCR-driven production of IP3 is partially diminished in T cells
decreased T cell proliferation ( J:83733 )
• mature T cells do not proliferate well in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)
• the T cell proliferation defect is restored by treatment with PDBu plus calcium ionophore
decreased interleukin-2 secretion ( J:83733 )
• IL-2 secretion is reduced in T cells in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)

hematopoietic system
abnormal T cell physiology ( J:83733 )
• mature CD3+T cells fail to mobilize similar intracellular calcium levels compared to wild-type in response to CD3 crosslinking, however calcium responses stimulated by calcium-ionophore remain intact
• reduction in TCR-induced NFAT activation in T lymphocytes
• TCR-driven production of IP3 is partially diminished in T cells
decreased T cell proliferation ( J:83733 )
• mature T cells do not proliferate well in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)
• the T cell proliferation defect is restored by treatment with PDBu plus calcium ionophore

cellular
decreased T cell proliferation ( J:83733 )
• mature T cells do not proliferate well in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)
• the T cell proliferation defect is restored by treatment with PDBu plus calcium ionophore




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory