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Allele Symbol Allele Name Allele ID |
Tg(PSEN1*L286V)1274Citr transgene insertion 1274, Martin Citron MGI:2664251 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• amyloid deposition is enhanced when the PSEN1 transgene is also expressed by mutants; deposition is noted by 30-45 days of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not exhibit neurodegeneration
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• spine density is increased 27% compared to in wild-type mice
• at 8 to 10 months, ramified spine density is decreased 33% compared to in wild-type mice
• however, spine density at 8 to 10 months is normal
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• at 4 to 5 months and at 8 to 10 months
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• at 13 to 14 months
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• at 4 to 5 months but not at 8 to 10 months
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• at 13 to 14 months
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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