Phenotypes associated with this allele

• Allele Symbol: Mylk^tm1Dmw
• Allele Name: targeted mutation 1, D Martin Watterson
• Allele ID: MGI:2662927
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mylk^tm1Dmw/Mylk^tm1Dmw	involves: C57BL/6	MGI:2662955

Genotype
MGI:2662955

hm1

• Allelic Composition: Mylk^tm1Dmw/Mylk^tm1Dmw
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:83394 )

• homozygotes are less susceptible to acute lung injury induced by i.p. injection of bacterial lipopolysaccharide (LPS) than similarly treated wild-type mice, as evidenced by absence of thrombi and leukocyte infiltration, lower lung-injury scores, absence of pulmonary edema, and lack of extravasation of RBCs across the endothelial cell (EC) barrier into the alveolar space at 24 hrs after LPS injection

• in addition, LPS-treated homozygotes show increased survival during subsequent mechanical ventilation-induced lung injury: 67% of homozygotes survive the full 60 min of ventilation whereas all of LPS-treated wild-type mice die within 20 min

• however, prior to LPS treatment, young adult homozygotes have normal lung morphology, and show no differences in litter size, body weight, fertility, or viability relative to wild-type littermates