About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnq2Nmf134
neuroscience mutagenesis facility, 134
MGI:2661797
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnq2Nmf134/Kcnq2Nmf134 C57BL/6J-Kcnq2Nmf134/J MGI:2661800
ht2
 		Kcnq2Nmf134/Kcnq2+ C57BL/6J-Kcnq2Nmf134 MGI:3797752
ht3
 		Kcnq2Nmf134/Kcnq2+ C57BL/6J-Kcnq2Nmf134/J MGI:2664162
cx4
 		Kcnq2Nmf134/Kcnq2+
Scn1atm1.1Aesc/Scn1a+ 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:4950073
cx5
 		Kcnq2Nmf134/Kcnq2+
Tg(Eno2-Scn2a1*)Q54Mm/0 		involves: C57BL/6J * SJL/J MGI:3797751


Genotype
MGI:2661800
hm1
Allelic
Composition		 Kcnq2Nmf134/Kcnq2Nmf134
Genetic
Background		 C57BL/6J-Kcnq2Nmf134/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2Nmf134 mutation (1 available); any Kcnq2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to electrical stimulation ( J:82238 )
• mice have a low threshold to electroconvulsive clonic seizures. i.e. when stimulated transcorneally for minimal seizures, mice respond not with minimal, but with intense seizure

nervous system
abnormal seizure response to electrical stimulation ( J:82238 )
• mice have a low threshold to electroconvulsive clonic seizures. i.e. when stimulated transcorneally for minimal seizures, mice respond not with minimal, but with intense seizure




Genotype
MGI:3797752
ht2
Allelic
Composition		 Kcnq2Nmf134/Kcnq2+
Genetic
Background		 C57BL/6J-Kcnq2Nmf134
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2Nmf134 mutation (1 available); any Kcnq2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:136510 )
• however, mice do not exhibit spontaneous seizures
• mice exhibit a reduced threshold to seizures induced by petylenetetrazol compared to wild-type mice
abnormal seizure response to electrical stimulation ( J:136510 )
• mice exhibit electrically induced seizures
• however, mice do not exhibit spontaneous seizures

nervous system
nervous system phenotype ( J:136510 )
N
• mice exhibit normal nervous system morphology
increased susceptibility to pharmacologically induced seizures ( J:136510 )
• mice exhibit a reduced threshold to seizures induced by petylenetetrazol compared to wild-type mice
• however, mice do not exhibit spontaneous seizures
abnormal seizure response to electrical stimulation ( J:136510 )
• mice exhibit electrically induced seizures
• however, mice do not exhibit spontaneous seizures




Genotype
MGI:2664162
ht3
Allelic
Composition		 Kcnq2Nmf134/Kcnq2+
Genetic
Background		 C57BL/6J-Kcnq2Nmf134/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2Nmf134 mutation (1 available); any Kcnq2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to electrical stimulation ( J:82238 )
• mutants appear to have a low threshold to electroconvulsive clonic seizures. i.e. when stimulated transcorneally for minimal seizures, the majority of mice respond not with minimal, but with intense seizure
• rearing, forelimb clonus and jaw clonus, and/or tonic hind limb extension defined the intensity of the seizure as high

nervous system
abnormal seizure response to electrical stimulation ( J:82238 )
• mutants appear to have a low threshold to electroconvulsive clonic seizures. i.e. when stimulated transcorneally for minimal seizures, the majority of mice respond not with minimal, but with intense seizure
• rearing, forelimb clonus and jaw clonus, and/or tonic hind limb extension defined the intensity of the seizure as high




Genotype
MGI:4950073
cx4
Allelic
Composition		 Kcnq2Nmf134/Kcnq2+
Scn1atm1.1Aesc/Scn1a+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2Nmf134 mutation (1 available); any Kcnq2 mutation (47 available)
Scn1atm1.1Aesc mutation (0 available); any Scn1a mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
convulsive seizures ( J:170734 )
• mutants begin to display spontaneous generalized seizures starting at P16, most being myoclonic jerks, a few generalized tonic-clonic seizures, and one mouse showing partial motor seizure
• generalized seizures are periodically followed by tonic extension of the hindlimbs
tonic-clonic seizures ( J:170734 )
• mutants show a few generalized tonic-clonic seizures

mortality/aging
decreased survivor rate ( J:170734 )
• 47% of mutants survive for more than 100 days
postnatal lethality, incomplete penetrance ( J:170734 )
• sporadic death begins to occur at P19, with 42% mortality by P25

nervous system
convulsive seizures ( J:170734 )
• mutants begin to display spontaneous generalized seizures starting at P16, most being myoclonic jerks, a few generalized tonic-clonic seizures, and one mouse showing partial motor seizure
• generalized seizures are periodically followed by tonic extension of the hindlimbs
tonic-clonic seizures ( J:170734 )
• mutants show a few generalized tonic-clonic seizures

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
generalized epilepsy with febrile seizures plus DOID:0060170 J:170734




Genotype
MGI:3797751
cx5
Allelic
Composition		 Kcnq2Nmf134/Kcnq2+
Tg(Eno2-Scn2a1*)Q54Mm/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2Nmf134 mutation (1 available); any Kcnq2 mutation (47 available)
Tg(Eno2-Scn2a1*)Q54Mm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:136510 )
• mice do not survive beyond 6 months of age
postnatal lethality ( J:136510 )
• lethality associated with seizures is greater than 90%

behavior/neurological
seizures ( J:136510 )
• mice exhibit a seizure phenotype that is more severe than in either heterozygote alone with seizures beginning at day 12 and resulting in greater than 90% lethality by 3 weeks of age
tonic-clonic seizures ( J:136510 )
• mice exhibit prolonged general tonic-clonic seizures

nervous system
seizures ( J:136510 )
• mice exhibit a seizure phenotype that is more severe than in either heterozygote alone with seizures beginning at day 12 and resulting in greater than 90% lethality by 3 weeks of age
tonic-clonic seizures ( J:136510 )
• mice exhibit prolonged general tonic-clonic seizures

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:136510




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory