vision/eye
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• as early as 3 weeks of age, mice exhibit vacuolization of a subset of cells in the photoreceptor layer with rapid progressive depletion of cone photoreceptors unlike wild-type mice
• only a few cones are observed at 5 months
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• cone numbers decrease as early as 3 weeks of age and only a few cones are observed at 5 months unlike in wild-type mice
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• mice exhibit some swollen and pyknotic cells in the inner nuclear layer unlike wild-type mice
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• at 6 weeks of age the dark-adapted electroretinogram is sub-normal and the light-adapted electroretinogram is extinguished
• at higher intensities the b-wave amplitude plateaus abnormally instead of continuing to increase
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nervous system
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• as early as 3 weeks of age, mice exhibit vacuolization of a subset of cells in the photoreceptor layer with rapid progressive depletion of cone photoreceptors unlike wild-type mice
• only a few cones are observed at 5 months
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• cone numbers decrease as early as 3 weeks of age and only a few cones are observed at 5 months unlike in wild-type mice
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