Phenotypes associated with this allele

• Allele Symbol: Hpgd^tm1Bhk
• Allele Name: targeted mutation 1, Beverly H Koller
• Allele ID: MGI:2657242
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpgd^tm1Bhk/Hpgd^tm1Bhk	involves: 129P2/OlaHsd	MGI:2657244
hm2	Hpgd^tm1Bhk/Hpgd^tm1Bhk	involves: 129P2/OlaHsd * C57BL/6	MGI:3622448

Genotype
MGI:2657244

hm1

• Allelic Composition: Hpgd^tm1Bhk/Hpgd^tm1Bhk
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:74466 )

• homozygotes die within 12-48 hours after birth

• administration of indomethacin, which inhibits PGE2 production, rescues neonatal lethality and ductus arteriosus patency

cardiovascular system

abnormal vascular regression ( J:74466 )

• newborn homozygotes fail to exhibit remodeling of the ductus arteriosus i.e. lifting of endothelial cells, fragmentation of elastic lamina, migration of smooth-muscle cells and obstruction of lumen by intimal thickening

patent ductus arteriosus ( J:74466 )

• newborn homozygotes exhibit a patent ductus arteriosus of a similar diameter to that of a full-term fetus

congestive heart failure ( J:74466 )

• newborn homozygotes die of congestive heart failure as a result of left-ventricle overload and exposure of the right ventricle to arterial pressures

homeostasis/metabolism

increased prostaglandin level ( J:74466 )

• newborn homozygotes exhibit significantly increased PGE2 levels; in contrast, TxB2 levels remain normal

• perinatal PGE2 levels remain abnormally elevated, intracellular cAMP levels do not change, and DA remodeling is inhibited

cellular

abnormal vascular regression ( J:74466 )

• newborn homozygotes fail to exhibit remodeling of the ductus arteriosus i.e. lifting of endothelial cells, fragmentation of elastic lamina, migration of smooth-muscle cells and obstruction of lumen by intimal thickening

patent ductus arteriosus ( J:74466 )

• newborn homozygotes exhibit a patent ductus arteriosus of a similar diameter to that of a full-term fetus

Genotype
MGI:3622448

hm2

• Allelic Composition: Hpgd^tm1Bhk/Hpgd^tm1Bhk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

abnormal prostaglandin level ( J:105183 )

• homozygotes exhibit no production of PGE-M, the major urinary metabolite of PGE2, providing evidence that disrupted catabolism of PGE2 contributes to elevated levels of bioactive PGE2