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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Amottm1Bhr
targeted mutation 1, Richard R Behringer
MGI:2656627
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Amottm1Bhr/Amottm1Bhr B6.129S7-Amottm1Bhr MGI:3832448
hm2
Amottm1Bhr/Amottm1Bhr involves: 129S7/SvEvBrd * C57BL/6 MGI:2656632
ot3
Amottm1Bhr/Y B6.129S7-Amottm1Bhr MGI:3832462
ot4
Amottm1Bhr/Y involves: 129S7/SvEvBrd * C57BL/6 MGI:2656633


Genotype
MGI:3832448
hm1
Allelic
Composition
Amottm1Bhr/Amottm1Bhr
Genetic
Background
B6.129S7-Amottm1Bhr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 75% of mutant mice die between E11 and E11.5

growth/size/body
• embryos are 85% the size of control littermates at E10.5

embryo
• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
• embryos are 85% the size of control littermates at E10.5
• placentas are 75% the size of control littermate placentas at E10.5, however the establishment of the placental layers and function are normal

cardiovascular system
• insufficient capillary formation in the somitic region
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected, however vessel diameter in the brain is twice the size of wild-type
• severe vascular insufficiency in the intersomitic region; the interconnecting paraneural blood vessels are missing and the remaining vessels are dilated and shorter
• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
• dilated vessels in the brain and yolk sac

nervous system
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected, however vessel diameter in the brain is twice the size of wild-type




Genotype
MGI:2656632
hm2
Allelic
Composition
Amottm1Bhr/Amottm1Bhr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8

embryo
• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
• ~ 90% of embryos at E7.5 have excessive folds at the cranial limiting furrow region
• the cranial limiting furrow region contains more than two cell layers and is disorganized
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
• visceral endoderm accumulates at the cranial limiting furrow of E7.5 mutants

cardiovascular system
• 62% of embryos are hemorrhagic at E7.5

cellular
• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced




Genotype
MGI:3832462
ot3
Allelic
Composition
Amottm1Bhr/Y
Genetic
Background
B6.129S7-Amottm1Bhr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 75% of mutant mice die between E11 and E11.5

growth/size/body
• embryos are 85% the size of control littermates at E10.5

embryo
• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
• embryos are 85% the size of control littermates at E10.5
• placentas are 75% the size of control littermate placentas at E10.5, however the establishment of the placental layers and function are normal

cardiovascular system
• insufficient capillary formation in the somitic region
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected however vessel diameter in the brain is twice the size of wild-type
• severe vascular insufficiency in the intersomitic region; the interconnecting paraneural blood vessels are missing and the remaining vessels are dilated and shorter
• VEGF-induced tubulogenesis is impaired in embryoid bodies
• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
• dilated vessels in the brain and yolk sac

nervous system
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected however vessel diameter in the brain is twice the size of wild-type




Genotype
MGI:2656633
ot4
Allelic
Composition
Amottm1Bhr/Y
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8

embryo
• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
• ~ 90% of embryos at E7.5 have excessive folds at the cranial limiting furrow region
• the cranial limiting furrow region contains more than two cell layers and is disorganized
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
• visceral endoderm accumulates at the cranial limiting furrow of E7.5 mutants

cardiovascular system
• 62% of embryos are hemorrhagic at E7.5

cellular
• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory