Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amottm1Bhr mutation
(0 available);
any
Amot mutation
(11 available)
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mortality/aging
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• 75% of mutant mice die between E11 and E11.5
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growth/size/body
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• embryos are 85% the size of control littermates at E10.5
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embryo
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• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
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• embryos are 85% the size of control littermates at E10.5
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• placentas are 75% the size of control littermate placentas at E10.5, however the establishment of the placental layers and function are normal
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cardiovascular system
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• insufficient capillary formation in the somitic region
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• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected, however vessel diameter in the brain is twice the size of wild-type
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• severe vascular insufficiency in the intersomitic region; the interconnecting paraneural blood vessels are missing and the remaining vessels are dilated and shorter
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• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
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• dilated vessels in the brain and yolk sac
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nervous system
|
|
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected, however vessel diameter in the brain is twice the size of wild-type
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amottm1Bhr mutation
(0 available);
any
Amot mutation
(11 available)
|
|
|
mortality/aging
|
|
• 50% of mutant embryos die around E7.5
|
growth/size/body
|
|
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
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embryo
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• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
|
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• ~ 90% of embryos at E7.5 have excessive folds at the cranial limiting furrow region
• the cranial limiting furrow region contains more than two cell layers and is disorganized
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• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
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• visceral endoderm accumulates at the cranial limiting furrow of E7.5 mutants
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cardiovascular system
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• 62% of embryos are hemorrhagic at E7.5
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cellular
|
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• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amottm1Bhr mutation
(0 available);
any
Amot mutation
(11 available)
|
|
|
mortality/aging
 |
• 75% of mutant mice die between E11 and E11.5
|
growth/size/body
|
|
• embryos are 85% the size of control littermates at E10.5
|
embryo
|
|
• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
|
|
|
• embryos are 85% the size of control littermates at E10.5
|
|
|
• placentas are 75% the size of control littermate placentas at E10.5, however the establishment of the placental layers and function are normal
|
cardiovascular system
|
|
• insufficient capillary formation in the somitic region
|
|
|
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected however vessel diameter in the brain is twice the size of wild-type
|
|
|
• severe vascular insufficiency in the intersomitic region; the interconnecting paraneural blood vessels are missing and the remaining vessels are dilated and shorter
• VEGF-induced tubulogenesis is impaired in embryoid bodies
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|
|
• E10.5 yolk sacs exhibit abnormal vascular patterning, containing vessels with increased diameter and some vessels that are anastomosed to form lagoon-like structures
|
|
|
• dilated vessels in the brain and yolk sac
|
nervous system
|
|
• mutants exhibit a less structured network of blood vessels in the brain that form lagoon-like structures with an accumulation of erythrocytes
• branching is not affected however vessel diameter in the brain is twice the size of wild-type
|
Allelic
Composition |
Amottm1Bhr/Y
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Genetic
Background |
involves: 129S7/SvEvBrd * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amottm1Bhr mutation
(0 available);
any
Amot mutation
(11 available)
|
|
|
mortality/aging
|
|
• 50% of embryos die around E7.5
|
growth/size/body
|
|
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
|
embryo
|
|
• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
|
|
|
• ~ 90% of embryos at E7.5 have excessive folds at the cranial limiting furrow region
• the cranial limiting furrow region contains more than two cell layers and is disorganized
|
|
|
• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
|
|
|
• visceral endoderm accumulates at the cranial limiting furrow of E7.5 mutants
|
cardiovascular system
|
|
• 62% of embryos are hemorrhagic at E7.5
|
cellular
|
|
• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
|
Analysis Tools