Mouse Genome Informatics
hm1
    Mefvtm1Chae/Mefvtm1Chae
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• macrophages exhibit resistance to apoptosis
• increase in the fever response to LPS injections
• mutants are hypersensitive to endotoxin; within an hour of LPS injection, mutants become more severely hypothermic than controls and mice treated with LPS and/or D-galactosamine, a hepatocyte-sensitizing agent, show increased lethality compared to controls

homeostasis/metabolism
• unchallenged mutants have several-hour intervals with body temperatures greater than 39 degrees Celcius more frequently than wild type and fevers that are unpredictable

cellular
• macrophages exhibit resistance to apoptosis

hematopoietic system
• macrophages exhibit resistance to apoptosis

Mouse Models of Human Disease
OMIM IDRef(s)
Familial Mediterranean Fever; FMF 249100 J:82763