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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mefvtm1Chae
targeted mutation 1, Jae Jin Chae
MGI:2655791
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mefvtm1Chae/Mefvtm1Chae either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) MGI:2655804


Genotype
MGI:2655804
hm1
Allelic
Composition
Mefvtm1Chae/Mefvtm1Chae
Genetic
Background
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mefvtm1Chae mutation (0 available); any Mefv mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages exhibit resistance to apoptosis
• increase in the fever response to LPS injections
• mutants are hypersensitive to endotoxin; within an hour of LPS injection, mutants become more severely hypothermic than controls and mice treated with LPS and/or D-galactosamine, a hepatocyte-sensitizing agent, show increased lethality compared to controls

homeostasis/metabolism
• unchallenged mutants have several-hour intervals with body temperatures greater than 39 degrees Celcius more frequently than wild type and fevers that are unpredictable

cellular
• macrophages exhibit resistance to apoptosis

hematopoietic system
• macrophages exhibit resistance to apoptosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Familial Mediterranean Fever; FMF 249100 J:82763





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory