All Phenotypes Plcb4<tm1Tyo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plcb4^tm1Tyo
targeted mutation 1, Tohru Yoshioka
MGI:2654917

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcb4^tm1Tyo/Plcb4^tm1Tyo	involves: C57BL/6J	MGI:2654920

Allelic Composition	Plcb4^tm1Tyo/Plcb4^tm1Tyo
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb4^tm1Tyo mutation (0 available); any Plcb4 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:72939 )

• the metabotropic glutamate receptor 1-mediated calcium response is reduced in the rostral cerebellum

reduced long-term depression ( J:72939 )

• Purkinje cells exhibit reduced long term depression (LTD) after a conjunctive stimulation protocol in the rostral cerebellum, whereas LTD is intact in caudal cerebellum

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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