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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Klf9tm1Yfk
targeted mutation 1, Yoshiaki Fujii-Kuriyama
MGI:2654224
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Klf9tm1Yfk/Klf9tm1Yfk B6.129P2-Klf9tm1Yfk/J MGI:6272001
hm2
Klf9tm1Yfk/Klf9tm1Yfk involves: 129P2/OlaHsd * C57BL/6J MGI:2654225


Genotype
MGI:6272001
hm1
Allelic
Composition
Klf9tm1Yfk/Klf9tm1Yfk
Genetic
Background
B6.129P2-Klf9tm1Yfk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf9tm1Yfk mutation (1 available); any Klf9 mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• females in which endometriosis is surgically induced show minimal endometriotic implant-associated growth and fibrosis similar to that seen in controls




Genotype
MGI:2654225
hm2
Allelic
Composition
Klf9tm1Yfk/Klf9tm1Yfk
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf9tm1Yfk mutation (1 available); any Klf9 mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• homozygotes exhibit only slight (insignificant) differences in locomotor activities, rearing behavior, and speed of movement or no differences in the rod-walking test, light-dark choice test, horizontal wire-hanging test, or gait measurements relative to wild-type littermates
• homozygotes exhibit a significant deficit in contextual freezing response, both immediately (immediate after shock freezing) and 1 day (delayed freezing) after the shock is presented
• however, homozygotes display normal jumping and vocalization reactions in response to increasing electrical foot shocks, indicating that pain sensitivity and physical response to pain are not significantly altered
• homozygotes display a performance deficit on the rotating rod test, failing to improve performance after daily training





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory