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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apptm1.1Cep
targeted mutation 1.1, Cephalon Inc
MGI:2652346
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apptm1.1Cep/Apptm1.1Cep involves: 129S1/Sv * 129X1/SvJ MGI:2652362
ht2
Apptm1.1Cep/App+ involves: 129S1/Sv * 129X1/SvJ MGI:2652363
cx3
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3611210


Genotype
MGI:2652362
hm1
Allelic
Composition
Apptm1.1Cep/Apptm1.1Cep
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1.1Cep mutation (0 available); any App mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased amyloidogenic processing of App

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:35500




Genotype
MGI:2652363
ht2
Allelic
Composition
Apptm1.1Cep/App+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1.1Cep mutation (0 available); any App mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased amyloidogenic processing of App

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:35500




Genotype
MGI:3611210
cx3
Allelic
Composition
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1.1Cep mutation (0 available); any App mutation (20 available)
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

homeostasis/metabolism
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:102425





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory