Mouse Genome Informatics
hm1
    Apptm1.1Cep/Apptm1.1Cep
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• increased amyloidogenic processing of App

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:35500


Mouse Genome Informatics
ht2
    Apptm1.1Cep/App+
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• increased amyloidogenic processing of App

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:35500


Mouse Genome Informatics
cx3
    Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf

involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

other phenotype
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:102425