Mouse Genome Informatics
hm1
     Apptm1.1Cep/Apptm1.1Cep
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
cellular
abnormal cell physiology ( J:35500 )
• increased amyloidogenic processing of App

Mouse Models of Human Disease
 OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:35500


Mouse Genome Informatics
ht2
     Apptm1.1Cep/App+
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
cellular
abnormal cell physiology ( J:35500 )
• increased amyloidogenic processing of App

Mouse Models of Human Disease
 OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:35500


Mouse Genome Informatics
cx3
     Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
nervous system
amyloid beta deposits ( J:66147 , J:102425 )
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

other phenotype
amyloid beta deposits ( J:66147 , J:102425 )
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease
 OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:102425