Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba1tm1.1Sud mutation
(0 available);
any
Apba1 mutation
(32 available)
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growth/size/body
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• mice exhibit slight but significant decrease in size compared to wild-type
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nervous system
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• mutants display normal paired pulse facilitation, use-dependent depression, posttetanic potentiation and long term potentiation
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• inhibitory post synaptic currents (IPSCs) from CA1 pyramidal cells exhibit a large increase in paired pulse depression at short interstimulus intervals of <100 ms compared to wild-type
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behavior/neurological
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• mutants display slightly increased ataxia index (area covered in 6 minutes/total distance traveled) compared to wild-type, indicating movement dysfunction
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba1tm1.1Sud mutation
(0 available);
any
Apba1 mutation
(32 available)
Apba2tm1.1Sud mutation
(0 available);
any
Apba2 mutation
(45 available)
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mortality/aging
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• double mutants display survival deficit, with only about 20% survival postnatal
• hours after birth, pups have no milk in their stomachs, become progressively weaker within twelve hours, and die within 24 hours
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growth/size/body
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• at 21 days of age, mutants are markedly smaller (runted) compared to littermates
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behavior/neurological
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• mutants display show major increases in ataxia index (area covered in 6 minutes/total distance traveled) compared to wild-type, indicating movement dysfunction
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nervous system
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• mutants display decreased basal synaptic strength compared to Apba1-null mice, similar to double Apba1/2 knockouts
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• mutants show significant decrease in relationship between size of presynaptic fiber volley (input) and resulting field EPSCs (output) compared to Apba1-null mice indicating decreased basal synaptic strength
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• repetitive stimulation produces a much higher degree of facilitation compared to Apba1-null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba1tm1.1Sud mutation
(0 available);
any
Apba1 mutation
(32 available)
Apba3tm1.1Sud mutation
(0 available);
any
Apba3 mutation
(22 available)
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mortality/aging
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• born in normal ratio; double mutants display survival deficit, with only ~20% survival postnatal
• hours after birth, pups have no milk in their stomachs, become progressively weaker within twelve hours, and die within 24 hours
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba1tm1.1Sud mutation
(0 available);
any
Apba1 mutation
(32 available)
Apba2tm1.1Sud mutation
(0 available);
any
Apba2 mutation
(45 available)
Apba3tm1.1Sud mutation
(0 available);
any
Apba3 mutation
(22 available)
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mortality/aging
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• triple mutants display survival deficit, with only ~20% survival postnatal
• hours after birth, pups have no milk in their stomachs, become progressively weaker within twelve hours, and die within 24 hours
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nervous system
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• mice display decreased basal synaptic strength compared to Apba1-null mice
• in culture, when neonatal neurons homozygous for floxed Apba1, Apba2 and Apba3 alleles are treated with lentiviral cre, a ~30% reduction in miniature spontaneous current frequency in both excitatory and inhibitory synapses compared to control neurons
• synaptic response to hypertonic sucrose application is significantly decreased
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• in response to hypertonic sucrose, currents are decreased ~45% in cultured, cre-treated neurons
• use-dependent depression in initially decreased at excitatory synapses during repetitive 10 Hz stimulation
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Analysis Tools