About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ros1tm2Cbm
targeted mutation 2, Carmen Birchmeier
MGI:2450662
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ros1tm2Cbm/Ros1tm2Cbm involves: 129P2/OlaHsd MGI:2664397


Genotype
MGI:2664397
hm1
Allelic
Composition
Ros1tm2Cbm/Ros1tm2Cbm
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ros1tm2Cbm mutation (0 available); any Ros1 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• in contrast to males, female homozygotes are fertile
• a reduced number of sperm cells is detected in the oviduct after mating females with mutant males, suggesting a sperm maturation defect
• male homozygotes show a primary defect in epididymal regionalization and differentiation
• tubules typically formed by tall columnar epithelial cells with long microvilli in the proximal part of the caput ("initial segment") are completely absent and replaced by tubules formed by low columar epithelial cells that resemble cells of the wild-type distal caput
• in contrast, the corpus and cauda epididymis, vas deferens, seminal glands, and testis appear histologically normal
• the mutant caput epididymis is reduced in size
• regionalization and terminal differentiation of the proximal epididymal epithelium is severely disrupted
• male homozygotes appear healthy and show normal mating behavior but are sterile
• mutant sperm are produced at normal numbers but are completely unable to fertilize in vivo
• however, mutant sperm can fertilize eggs in vitro, and the fertilized eggs develop in vitro or in vivo with no obvious defects

cellular
• a reduced number of sperm cells is detected in the oviduct after mating females with mutant males, suggesting a sperm maturation defect





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory