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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxk1tm1Djg
targeted mutation 1, Daniel J Garry
MGI:2450307
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxk1tm1Djg/Foxk1tm1Djg involves: 129S4/SvJae MGI:3655082
cx2
 		Cdkn1atm1Tyj/Cdkn1atm1Tyj
Foxk1tm1Djg/Foxk1tm1Djg 		involves: 129S2/SvPas * 129S4/SvJae MGI:3655091
cx3
 		Dmdmdx/Dmdmdx
Foxk1tm1Djg/Foxk1tm1Djg 		involves: 129S4/SvJae * C57BL/10ScSn MGI:3655088
cx4
 		Dmdmdx/Y
Foxk1tm1Djg/Foxk1tm1Djg 		involves: 129S4/SvJae * C57BL/10ScSn MGI:3655090
cx5
 		Dmdmdx/Dmd+
Foxk1tm1Djg/Foxk1+ 		involves: 129S4/SvJae * C57BL/10ScSn MGI:3655093


Genotype
MGI:3655082
hm1
Allelic
Composition		 Foxk1tm1Djg/Foxk1tm1Djg
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxk1tm1Djg mutation (0 available); any Foxk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:62225 )
• year old mice are 60% the size of age matched controls

muscle
abnormal muscle precursor cell morphology ( J:81688 )
• pool of myogenic progenitor cells in skeletal muscle is reduced by 71%
impaired skeletal muscle regeneration ( J:62225 )
• repair of skeletal muscle damaged by cardiotoxin injection is impaired
• eventual regeneration is accompanied by extensive replacement of muscle with fat

cellular
abnormal cell cycle ( J:81688 )
• cell cycle progression is disrupted
• increased numbers of G0 and G1 cells
• decreased numbers of S and G2/M cells




Genotype
MGI:3655091
cx2
Allelic
Composition		 Cdkn1atm1Tyj/Cdkn1atm1Tyj
Foxk1tm1Djg/Foxk1tm1Djg
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Tyj mutation (3 available); any Cdkn1a mutation (60 available)
Foxk1tm1Djg mutation (0 available); any Foxk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:81688 )
N
• G0/G1 arrest of cell cycle is prevented

growth/size/body
growth/size/body region phenotype ( J:81688 )
N
• growth retardation is prevented
• there is no significant size difference from controls

muscle
muscle phenotype ( J:81688 )
N
• no impairment in skeletal muscle regeneration is observed




Genotype
MGI:3655088
cx3
Allelic
Composition		 Dmdmdx/Dmdmdx
Foxk1tm1Djg/Foxk1tm1Djg
Genetic
Background		 involves: 129S4/SvJae * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (30 available); any Dmd mutation (153 available)
Foxk1tm1Djg mutation (0 available); any Foxk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:62225 )
• all are dead by 3 months of age
postnatal lethality, incomplete penetrance ( J:62225 )
• die within a few weeks of birth
• few survive beyond weaning

behavior/neurological
weakness ( J:62225 )
• fragile and weak

muscle
skeletal muscle fibrosis ( J:62225 )
• fibrosis in muscles of the chest wall, the diaphragm and the intercostals

cellular

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
 J:62225




Genotype
MGI:3655090
cx4
Allelic
Composition		 Dmdmdx/Y
Foxk1tm1Djg/Foxk1tm1Djg
Genetic
Background		 involves: 129S4/SvJae * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (30 available); any Dmd mutation (153 available)
Foxk1tm1Djg mutation (0 available); any Foxk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:62225 )
• all are dead by 3 months of age
postnatal lethality, incomplete penetrance ( J:62225 )
• die within a few weeks of birth
• few survive beyond weaning

behavior/neurological
weakness ( J:62225 )
• fragile and weak

muscle
skeletal muscle fibrosis ( J:62225 )
• fibrosis in muscles of the chest wall, the diaphragm and the intercostals

cellular

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
 J:62225




Genotype
MGI:3655093
cx5
Allelic
Composition		 Dmdmdx/Dmd+
Foxk1tm1Djg/Foxk1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (30 available); any Dmd mutation (153 available)
Foxk1tm1Djg mutation (0 available); any Foxk1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:62225 )
• mice survive to adulthood but remain small in size

muscle
skeletal muscle necrosis ( J:62225 )
• extensive muscle necrosis is observed up to 6 months of age

cellular
skeletal muscle necrosis ( J:62225 )
• extensive muscle necrosis is observed up to 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory