Phenotypes associated with this allele
Allelic Composition |
Btktm1Gsv/Btk+
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Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Gsv mutation
(0 available);
any
Btk mutation
(22 available)
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immune system
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• decreased number of B220+ cells peripherally
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• reduced numbers of mature IgM-IgD+ B cells
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• deficiency of CD5+ B cells in the peritoneum for B cells expressing both the mutant and the wild-type allele
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hematopoietic system
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• decreased number of B220+ cells peripherally
|
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• reduced numbers of mature IgM-IgD+ B cells
|
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• deficiency of CD5+ B cells in the peritoneum for B cells expressing both the mutant and the wild-type allele
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation
(0 available);
any
Blnk mutation
(76 available)
Btktm1Gsv mutation
(0 available);
any
Btk mutation
(22 available)
|
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immune system
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• B cell development is completely blocked
|
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• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
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• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
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neoplasm
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• increased frequency of pre-B cell lymphomas
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hematopoietic system
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• B cell development is completely blocked
|
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• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
|
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• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation
(0 available);
any
Blnk mutation
(76 available)
Btktm1Gsv mutation
(0 available);
any
Btk mutation
(22 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation
(0 available)
|
|
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immune system
|
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
|
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• IgG3 levels remain severely reduced
|
neoplasm
N |
• tumor suppressor function is restored
|
hematopoietic system
|
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
|
|
• IgG3 levels remain severely reduced
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Gsv mutation
(0 available);
any
Btk mutation
(22 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation
(0 available)
|
|
|
immune system
N |
• calcium signaling of splenic B cells is restored
|
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• B cell apoptosis is reduced compared to similar mice lacking the transgene
|
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• restored B220+ cell numbers peripherally
|
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• deficiency of CD5+ B cells in the peritoneum remains
|
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• differentiation is partially restored
|
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• decreased lambda light chain usage
|
hematopoietic system
|
• B cell apoptosis is reduced compared to similar mice lacking the transgene
|
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• restored B220+ cell numbers peripherally
|
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• deficiency of CD5+ B cells in the peritoneum remains
|
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• differentiation is partially restored
|
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• decreased lambda light chain usage
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cellular
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• B cell apoptosis is reduced compared to similar mice lacking the transgene
|
Allelic Composition |
Btktm1Gsv/Y
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Gsv mutation
(0 available);
any
Btk mutation
(22 available)
|
|
|
immune system
|
• development through to large pre-B cell stage is normal
• transition from pre-B to immature B cell is impaired
|
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• reduced IgM+IgD- to about 70% of normal numbers at 5 weeks of age
|
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• decreased number of B220+ cells peripherally
• thymocyte and T cell numbers are unaffected
|
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• mature IgMlowIgDhigh are nearly absent
|
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• deficiency of CD5+ B cells in the peritoneum
|
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• significantly reduced calcium signaling in splenic B cells
|
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• decreased lambda light chain usage
|
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• IgG3 reduced 20% at 5 weeks of age
|
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• reduced 50% at 5 weeks of age
|
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• no response to T cell independent type II antigens
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hematopoietic system
|
• development through to large pre-B cell stage is normal
• transition from pre-B to immature B cell is impaired
|
|
• reduced IgM+IgD- to about 70% of normal numbers at 5 weeks of age
|
|
• decreased number of B220+ cells peripherally
• thymocyte and T cell numbers are unaffected
|
|
• mature IgMlowIgDhigh are nearly absent
|
|
• deficiency of CD5+ B cells in the peritoneum
|
|
• significantly reduced calcium signaling in splenic B cells
|
|
• decreased lambda light chain usage
|
|
• IgG3 reduced 20% at 5 weeks of age
|
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• reduced 50% at 5 weeks of age
|