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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Car8wdl
waddles
MGI:2449035
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Car8wdl/Car8wdl C57BLKS/J-Car8wdl/GrsrJ MGI:5766909


Genotype
MGI:5766909
hm1
Allelic
Composition
Car8wdl/Car8wdl
Genetic
Background
C57BLKS/J-Car8wdl/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car8wdl mutation (1 available); any Car8 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor learning on the rotarod improves at P30 but not over the 12 trials at P90 or P360
• mice develop a severe tremor with age
• as tremor amplitude increases with age, the frequency decreases
• side-to-side movements are obvious by 2 weeks of age
• motor performance on the rotarod declines with age
• chlorzoxazone treatment improves motor performance on the rotarod, although it does not completely rescue the phenotype to control levels
• this mutant has an odd waddling walk throughout life

hearing/vestibular/ear
• Background Sensitivity: hearing of mutant and control is abnormal by 7 months of age due to C57BLKS/J background

nervous system
• the patterning of the cerebellum into zones is spatially and temporally altered
• molecular layer thickness is decreased at P15 and P30, but not at later stages, suggesting a developmental delay
• however, mice do not exhibit cerebellar neurodegeneration or Purkinje cell loss with age
• the wiring of cerebellar sensory maps is poorly coordinated
• the adult spinocerebellar sensory map is not sharply delineated, with the topography of the afferent map less clear at P90 compared to P30
• cuneocerebellar and spinocerebellar proprioceptive pathways exhibit overlapping domains
• chlorzoxazone does not reconfirgure the miswired cerebellar circuit map
• Purkinje cell activity is severely impaired, with Purkinje cells firing with long pauses
• Purkinje cells fire erratically on the whole, however they also exhibit higher regularity during firing
• Purkinje cell firing is already compromised in pre-weaned developing pups, with Purkinje cells firing more rapidly and with even less regularity than controls
• chlorzoxazone, a muscle relaxant, corrects several properties of Purkinje cell firing





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory