Phenotypes associated with this allele

• Allele Symbol: Igfbp1^tm1Taub
• Allele Name: targeted mutation 1, Rebecca Taub
• Allele ID: MGI:2448461
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igfbp1^tm1Taub/Igfbp1^tm1Taub	involves: 129X1/SvJ * C57BL/6	MGI:3603676

Genotype
MGI:3603676

hm1

• Allelic Composition: Igfbp1^tm1Taub/Igfbp1^tm1Taub
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte apoptosis ( J:81123 )

• increased sensitivity to hepatocyte apoptosis after injection with antiFas antibody

• increased levels of apoptotic hepatocyte death resulting from CCl₄ exposure

hepatic necrosis ( J:81123 , J:81817 )

• increased levels of necrtotic hepatocyte death resulting from CCl₄ exposure (J:81123)

• regions of necrosis immediately following 2/3 partial hepatectomy but not 48 hours later (J:81817)

focal hepatic necrosis ( J:81123 )

• development of areas of hemorrhage, necrosis and destruction of parenchymal architecture after injection with antiFas antibody

• CCl₄ causes more rapid, severe, and extensive injury

liver inflammation ( J:81123 )

• mild inflammatory infiltrate and congestion as a result of CCl₄ exposure

hepatic steatosis ( J:81123 )

• panlobular steatosis as a result of CCl₄ exposure

delayed liver regeneration ( J:81817 )

• delay in initiation of DNA synthesis following partial hepatectomy

impaired liver regeneration ( J:81817 )

• levels of DNA synthesis reduced 30-40% following partial hepatectomy

cellular

increased hepatocyte apoptosis ( J:81123 )

• increased sensitivity to hepatocyte apoptosis after injection with antiFas antibody

• increased levels of apoptotic hepatocyte death resulting from CCl₄ exposure

hepatic necrosis ( J:81123 , J:81817 )

• increased levels of necrtotic hepatocyte death resulting from CCl₄ exposure (J:81123)

• regions of necrosis immediately following 2/3 partial hepatectomy but not 48 hours later (J:81817)

focal hepatic necrosis ( J:81123 )

• development of areas of hemorrhage, necrosis and destruction of parenchymal architecture after injection with antiFas antibody

• CCl₄ causes more rapid, severe, and extensive injury

immune system

liver inflammation ( J:81123 )

• mild inflammatory infiltrate and congestion as a result of CCl₄ exposure