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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ebi3tm1Rsb
targeted mutation 1, Richard Blumberg
MGI:2448308
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ebi3tm1Rsb/Ebi3tm1Rsb involves: 129X1/SvJ * C57BL/6 MGI:3689994


Genotype
MGI:3689994
hm1
Allelic
Composition
Ebi3tm1Rsb/Ebi3tm1Rsb
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebi3tm1Rsb mutation (2 available); any Ebi3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• statistically significant reduction in invariant natural killer cells in the liver
• remaining natural killer cells have a reduced ability to produce IL-4
• proportion of Th1 cells increases later in parasitic infections when the infection is resolving
• proportion of Th2 is higher early in parasitic infects but not later
• lower portion of Th2 cells although levels can be stimulated to normal
• resistant to Th2 mediated oxazolone-induced colitis
• Th1 mediated colitis proceeds normally
• unstimulated CD4+ cells produce moderately increased levels of IFN-gamma
• levels after stimulation are less than controls 2-4 hours after stimulation but reach normal levels at 24 hours
• after stimulation of CD4+ cells, lower production of IL-4 than in controls
• serum levels of IL-4 are undetectable after stimulation
• enhanced susceptibility to Leishmania major at lower physiologically relevant doses
• larger lesions after L. major infection, 4X the size in controls at 6 week
• higher parasite burdens at site of infection, peaking at 6 weeks
• parasite level in spleens reaches 44X that of controls at 7 weeks but decreases after 8 weeks and infection is resolved by 14 weeks

digestive/alimentary system
• resistant to Th2 mediated oxazolone-induced colitis
• Th1 mediated colitis proceeds normally

hematopoietic system
• statistically significant reduction in invariant natural killer cells in the liver
• remaining natural killer cells have a reduced ability to produce IL-4
• proportion of Th1 cells increases later in parasitic infections when the infection is resolving
• proportion of Th2 is higher early in parasitic infects but not later
• lower portion of Th2 cells although levels can be stimulated to normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory