Analysis Tools
immune system
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• statistically significant reduction in invariant natural killer cells in the liver
• remaining natural killer cells have a reduced ability to produce IL-4
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• proportion of Th1 cells increases later in parasitic infections when the infection is resolving
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• proportion of Th2 is higher early in parasitic infects but not later
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• lower portion of Th2 cells although levels can be stimulated to normal
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• resistant to Th2 mediated oxazolone-induced colitis
• Th1 mediated colitis proceeds normally
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• unstimulated CD4+ cells produce moderately increased levels of IFN-gamma
• levels after stimulation are less than controls 2-4 hours after stimulation but reach normal levels at 24 hours
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• after stimulation of CD4+ cells, lower production of IL-4 than in controls
• serum levels of IL-4 are undetectable after stimulation
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• enhanced susceptibility to Leishmania major at lower physiologically relevant doses
• larger lesions after L. major infection, 4X the size in controls at 6 week
• higher parasite burdens at site of infection, peaking at 6 weeks
• parasite level in spleens reaches 44X that of controls at 7 weeks but decreases after 8 weeks and infection is resolved by 14 weeks
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digestive/alimentary system
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• resistant to Th2 mediated oxazolone-induced colitis
• Th1 mediated colitis proceeds normally
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hematopoietic system
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• statistically significant reduction in invariant natural killer cells in the liver
• remaining natural killer cells have a reduced ability to produce IL-4
|
|
• proportion of Th1 cells increases later in parasitic infections when the infection is resolving
|
|
• proportion of Th2 is higher early in parasitic infects but not later
|
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• lower portion of Th2 cells although levels can be stimulated to normal
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