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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gclmtm1Tdal
targeted mutation 1, Timothy P Dalton
MGI:2447852
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gclmtm1Tdal/Gclmtm1Tdal B6.129-Gclmtm1Tdal MGI:5519057
hm2
Gclmtm1Tdal/Gclmtm1Tdal involves: 129 * C57BL/6J MGI:3757552


Genotype
MGI:5519057
hm1
Allelic
Composition
Gclmtm1Tdal/Gclmtm1Tdal
Genetic
Background
B6.129-Gclmtm1Tdal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gclmtm1Tdal mutation (0 available); any Gclm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fewer parvalbumin (PV) labeled cells in the anterior cingulate cortex by 180 days of age
• higher proportion of PV cells are surrounded by aggrecan-enriched perineuronal nets
• induced rhythmic neuronal beta and gamma oscillations are weaker at 180 days than they are in controls

cellular
• increased oxidative stress in the anterior cingulate cortex at 90 days of age
• aggrecan-enriched perineuronal nets are reduced by oxidative stress
• sensitivity to oxidative stress is greater at 20 days of age before formation of aggrecan-enriched perineuronal nets




Genotype
MGI:3757552
hm2
Allelic
Composition
Gclmtm1Tdal/Gclmtm1Tdal
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gclmtm1Tdal mutation (0 available); any Gclm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• kidney and pancreas cysteine levels are decreased to 9% and 35%, respectively, of wild-type levels
• cysteine plasma levels are decreased 40% compared to wild-type levels

cellular
• mouse fetal fibroblast cells are 10-fold more sensitive to hydrogen peroxide treatment





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/19/2021
MGI 6.16
The Jackson Laboratory