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Allele Symbol Allele Name Allele ID |
Muc1tm1Gend targeted mutation 1, Sandra J Gendler MGI:2447730 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• development of mammary tumors was similar to that in wild-type mice but growth was slower
• tumors were significantly smaller by 124 days of age
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| N |
• normal ocular surface phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• firmly adherent layer of mucus is thinner than in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fatty acid absorption was normal
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• by the small intestine
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• fatty acid absorption was normal
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• by the small intestine
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• less cholesterol crystallization
• gallstones in fewer mice, 25% of mice at 56 days on a lithogenic diet as compared to 60% of wild-type mice on the same diet for the same length of time
• smaller gallstones
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• reduced glycoprotein secretion and less accumulation of mucin gel when on a "lithogenic" diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite prevalence of lung foci in mice expressing Tg(WapTgfa)215Bri alone in a C57BL/6 background, no metastatic adenocarcinomas or lymphomas are observed in the lung
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• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
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• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
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• mice exhibit fewer hyperplastic foci than in mice expressing Tg(WapTgfa)215Bri alone
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• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
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• mice exhibit fewer hyperplastic foci than in mice expressing Tg(WapTgfa)215Bri alone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• onset of mammary tumors was considerably delayed
• tumors were P-type
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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