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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT14-cre/PGR)1Der
transgene insertion 1, Dennis R Roop
MGI:2447651
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Krt10tm1Der/Krt10tm1Der
Tg(KRT14-cre/PGR)1Der/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR MGI:2652793
cn2
Krt10tm1Der/Krt10+
Tg(KRT14-cre/PGR)1Der/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR MGI:2652794
cn3
Krt14tm1Der/Krt14+
Tg(KRT14-cre/PGR)1Der/?
involves: 129X1/SvJ * FVB * ICR MGI:3812200


Genotype
MGI:2652793
cn1
Allelic
Composition
Krt10tm1Der/Krt10tm1Der
Tg(KRT14-cre/PGR)1Der/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt10tm1Der mutation (0 available); any Krt10 mutation (10 available)
Tg(KRT14-cre/PGR)1Der mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die shortly after birth

integument
• complete disintegration of the stratum spinosum
• severe blistering and erosion of the skin




Genotype
MGI:2652794
cn2
Allelic
Composition
Krt10tm1Der/Krt10+
Tg(KRT14-cre/PGR)1Der/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt10tm1Der mutation (0 available); any Krt10 mutation (10 available)
Tg(KRT14-cre/PGR)1Der mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• paws exhbit epidermal hyperkeratosis after onset of hair growth; hyperkeratosis persisted 6 months after initial RU486 treatment
• blisters develop after 3-5 topical treatments with RU486
• animals develop mild scaling




Genotype
MGI:3812200
cn3
Allelic
Composition
Krt14tm1Der/Krt14+
Tg(KRT14-cre/PGR)1Der/?
Genetic
Background
involves: 129X1/SvJ * FVB * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm1Der mutation (0 available); any Krt14 mutation (6 available)
Tg(KRT14-cre/PGR)1Der mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• after application of a topical antiprogestin, RU486, to the forelimbs and chest of newborn pups so that the cre transgene translocates from the cytoplasm to the nucleus of epidermal cells and becomes active, mice developed blisters filled with fluid on the front legs and paws
• blistering occurs within the basal layer of the epidermis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epidermolysis bullosa simplex Dowling-Meara type DOID:0060735 OMIM:131760
J:67320





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory