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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PSEN1)5Dbo
transgene insertion 5, David R Borchelt
MGI:2447335
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL MGI:5471581
cx2
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo MGI:3718026
cx3
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
involves: 129 * C3H/HeJ * C57BL/6 MGI:5428447
cx4
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0
involves: 129P2/OlaHsd MGI:5428425
cx5
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3663620
cx6
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3720017
cx7
Tg(APPSWE)2576Kha/0
Tg(PSEN1)5Dbo/0
involves: C57BL/6 * SJL MGI:5463430
tg8
Tg(PSEN1)5Dbo/0 involves: C3H/HeJ * C57BL/6J MGI:3663622


Genotype
MGI:5471581
cn1
Allelic
Composition
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (91 available)
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy
• activation of astrocytes is enhanced compared to controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 1 year of age

homeostasis/metabolism
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy




Genotype
MGI:3718026
cx2
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Genetic
Background
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females

behavior/neurological
• poor retention latency exhibited in light-dark step through box
• escape latencies across trial blocks in left-right discrimination learning are elevated and decrease little in comparison to decreased escape latencies exhibited in controls
• required higher trials to reach criterion and committed more errors in comparison to controls
• increased duration of immobility in Porsolt forced swim test
• increased irritability in response to touch escape test as compared to control
• poor nest building ability in comparison to controls

integument
• increased irritability in response to touch escape test as compared to control

homeostasis/metabolism
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females




Genotype
MGI:5428447
cx3
Allelic
Composition
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
Tlr2tm1Kir mutation (2 available); any Tlr2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention is reduced in passive avoidance tests involving electric shock training to prevent movement from a lighted area to a dark chamber
• retention of spatial memory in T-water maze tests declines as early as 3 months after acquisition, faster than for transgenics alone
• acquisition of spatial memory in T-water maze tests is normal

nervous system
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months
• higher brain levels of Abeta1-42

homeostasis/metabolism
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months
• higher brain levels of Abeta1-42




Genotype
MGI:5428425
cx4
Allelic
Composition
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno mutation (0 available); any Hprt mutation (1256 available)
Tg(PSEN1)5Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 5 months, mice exhibit impaired social recognition memory compared with control mice
• at 12 months, mice lack social recognition memory unlike control mice
• impaired at 8 months
• amnesia at 12 months
• at 12 months, mice exhibit impaired object recognition following spatial displacement compared with control mice
• impaired at 12 months
• mice exhibit higher swim speeds compared with control mice
• at 12 months, mice fail to exhibit a decline in activity during the day phase unlike control mice
• at 5 months mice exhibit increased wake time compared with control mice
• at 5 and 12 months, mice exhibit a decrease in rapid eye movement (REM) sleep compared with control mice
• at 5 months, mice exhibit a reduction in nonREM sleep compared with control mice
• at 12 months mice exhibit longer latency to sleep onset compared with control mice

nervous system
N
• mice do not develop fibrillary plaques or tangles
• mice exhibit a slowing of electroencephalogram compared with control mice
• mice exhibit faster decay of long term potentiation compared with control mice
• however, post-tetanic potentiation is normal

homeostasis/metabolism
• mice exhibit early and progressive brain glucose metabolism compared with control mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:180977




Genotype
MGI:3663620
cx5
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• associated with dystropic neuritis in cortex and hippocampus
• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus
• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons

homeostasis/metabolism
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)




Genotype
MGI:3720017
cx6
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation

homeostasis/metabolism
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation




Genotype
MGI:5463430
cx7
Allelic
Composition
Tg(APPSWE)2576Kha/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSWE)2576Kha mutation (3 available)
Tg(PSEN1)5Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dense amyloid beta plaques in the cortex and hippocampus, but not in the adrenal medulla
• amperometric recordings from chromaffin cells stimulated with a 10 second 70 mM potassium pulse indicate that the quantity of catecholamines released during the initiation of the fusion pore is 50% smaller in mutants than in controls
• chromaffin cells exhibit smaller quantal size and faster kinetics of single exocytotic events (45% lower spike half-width, 60% smaller quantal size, 50% lower decay time) and spike feet show 60% smaller quantal size
• mutants, however, exhibit normal innervation by splanchnic cholinergic nerve terminals of chromaffin cells

homeostasis/metabolism
• chromaffin cells release 50% less catecholamine (mean quantal content released per vesicle is halved) in response to a 10 second 70 mM potassium pulse
• dense amyloid beta plaques in the cortex and hippocampus, but not in the adrenal medulla

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:191088




Genotype
MGI:3663622
tg8
Allelic
Composition
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no immunoreactive amyloid beta deposits, neuron loss or reactive astrogliosis observed in cortex or hippocampus from 9 or 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory