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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgap6/Hccs/Mid1tm1Hzo
targeted mutation 1, Huda Y Zoghbi
MGI:2447298
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo involves: 129S7/SvEvBrd MGI:3578510
cn2
 		Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Tg(EIIa-cre)C5379Lmgd/? 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3580085
cn3
 		Arhgap6/Hccs/Mid1tm1Hzo/Y
Tg(EIIa-cre)C5379Lmgd/? 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3580086
cn4
 		Arhgap6/Hccs/Mid1tm1Hzo/Mid1+
Tg(EIIa-cre)C5379Lmgd/? 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3580091
ot5
 		Arhgap6/Hccs/Mid1tm1Hzo/Y involves: 129S7/SvEvBrd MGI:3578511


Genotype
MGI:3578510
hm1
Allelic
Composition		 Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Mid1 mutation (195 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3580085
cn2
Allelic
Composition		 Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Mid1 mutation (195 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80528 )
• 15 of 21 embryos abnormal at E9.5 and E10.5
• mosaic animals were present and were healthy and fertile
• no homozygous mice born

embryo
abnormal embryo development ( J:80528 )
• many embryos undergoing resorption by E9.5-E10.5
abnormal gastrulation ( J:80528 )
• gastrulation defects

growth/size/body
embryonic growth retardation ( J:80528 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
microphthalmia DOID:10629 J:80528




Genotype
MGI:3580086
cn3
Allelic
Composition		 Arhgap6/Hccs/Mid1tm1Hzo/Y
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Mid1 mutation (195 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80528 )
• no hemizygous mice born
• 15 of 21 embryos abnormal at E9.5 and E10.5
• mosaic animals were present and were healthy and fertile

embryo
abnormal embryo development ( J:80528 )
• many embryos undergoing resorption by E9.5-E10.5
abnormal gastrulation ( J:80528 )
• gastrulation defects

growth/size/body
embryonic growth retardation ( J:80528 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
microphthalmia DOID:10629 J:80528




Genotype
MGI:3580091
cn4
Allelic
Composition		 Arhgap6/Hccs/Mid1tm1Hzo/Mid1+
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Mid1 mutation (195 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80528 )
• no heterozygotes born

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
microphthalmia DOID:10629 J:80528




Genotype
MGI:3578511
ot5
Allelic
Composition		 Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Mid1 mutation (195 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory