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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Snai2tm1Look
targeted mutation 1, A Thomas Look
MGI:2447174
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Snai2tm1Look/Snai2tm1Look involves: 129X1/SvJ * C57BL/6 MGI:2653374


Genotype
MGI:2653374
hm1
Allelic
Composition
Snai2tm1Look/Snai2tm1Look
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2tm1Look mutation (0 available); any Snai2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exposed to semi-lethal doses of gamma-irradiation die more quickly and in greater numbers than controls; gastrointestinal mucosa appear normal in moribund mice; authors suggest premature lethality is due to damage to bone marrow progenitor cells

growth/size/body
• evident after birth

hematopoietic system
N
• circulating blood cell counts were similar to controls
• number of hematopoietic colony-forming progenitors were increased compared to control values; these cells appeared to be more sensitive to radiation-induced apoptosis than controls

immune system
N
• the numbers of B and T cells, the mitogenic responses of splenic and thymic lymphocytes and the serum levels of the immunoglobulins were similar to controls
• variable degrees of inflammation; almost all homozygotes develop swollen eyelids

vision/eye
• variable degrees of inflammation; almost all homozygotes develop swollen eyelids

homeostasis/metabolism
• mice exposed to semi-lethal doses of gamma-irradiation die more quickly and in greater numbers than controls; gastrointestinal mucosa appear normal in moribund mice; authors suggest premature lethality is due to damage to bone marrow progenitor cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory