Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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• CD4 expression is derepressed in CD8+ cells
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hematopoietic system
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• CD4 expression is derepressed in CD8+ cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation
(0 available);
any
Rr96 mutation
(0 available)
Zbtb7btm1Tani mutation
(1 available);
any
Zbtb7b mutation
(24 available)
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hematopoietic system
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• virtually all T cells found in the lymph node are double-positive T cells
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immune system
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• virtually all T cells found in the lymph node are double-positive T cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation
(0 available);
any
Rr96 mutation
(0 available)
Zbtb7btm1Itan mutation
(0 available);
any
Zbtb7b mutation
(24 available)
Zbtb7btm1Tani mutation
(1 available);
any
Zbtb7b mutation
(24 available)
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immune system
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• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
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• CD8+ T cells are almost absent in the periphery
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hematopoietic system
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• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
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• CD8+ T cells are almost absent in the periphery
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation
(0 available);
any
Rr96 mutation
(0 available)
Tfap4tm1.1Litt mutation
(0 available);
any
Tfap4 mutation
(92 available)
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hematopoietic system
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• in vivo, Cd4 silencing in immature thymocytes and effector/memory CD8+ T cells is impaired
• however, in vitro Cd4 silencing in activated CD8+ T cells is normal
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immune system
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• in vivo, Cd4 silencing in immature thymocytes and effector/memory CD8+ T cells is impaired
• however, in vitro Cd4 silencing in activated CD8+ T cells is normal
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