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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il21rtm1Wjl
targeted mutation 1, Warren J Leonard
MGI:2446509
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il21rtm1Wjl/Il21rtm1Wjl involves: 129 * C57BL/6 MGI:3813931
hm2
Il21rtm1Wjl/Il21rtm1Wjl NOD.Cg-Il21rtm1Wjl MGI:3814064
cx3
Il21rtm1Wjl/Il21rtm1Wjl
X/Yaa
BXSB.129(Cg)-Il21rtm1Wjl/Dcr MGI:3835838
cx4
Il21rtm1Wjl/Il21rtm1Wjl
Il4tm1Cgn/Il4tm1Cgn
involves: 129 * C57BL/6 MGI:3813932


Genotype
MGI:3813931
hm1
Allelic
Composition
Il21rtm1Wjl/Il21rtm1Wjl
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Wjl mutation (6 available); any Il21r mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• serum levels of IgE in nave mice are higher than in controls
• ovalbumin immunized mice have variable total IgE levels with some mice having levels similar to wild-type and some mice having 3- to 6- fold higher amounts
• total IgE production is increased about 50-fold after KLH immunization with similar increases with antigen specific antibody
• IgE levels are 20- to 25- fold greater than controls 100 days after infection with toxoplasma gondii
• serum levels of IgG1 in nave mice are lower than in controls
• after immunization with ovalbumin, the normal increase in IgG1 seen in wild-type mice is markedly impaired in these mice
• in immunized mice, total serum IgG1 is 4 to 5% of wild-type and levels of antigen-specific antibody is 0.1% of that in wild-type
• an impaired IgG1 response is also observed after keyhole limpet hemocyanin (KLH) immunization, with antigen specific antibodies being 1/10 of that found in wild-type
• IgG1 levels are third of controls 100 days after infection with toxoplasma gondii
• IgG2a levels are lower than controls 100 days after infection with toxoplasma gondii
• serum levels of IgG2b in nave mice are lower than in controls
• after ovalbumin immunization, levels of antigen specific IgGb2 antibody are significantly lower
• an impaired IgG2b response is also observed after KLH immunization, with antigen specific antibodies being 1/10 of that found in wild-type
• IgG2b levels are lower than controls 100 days after infection with toxoplasma gondii
• after ovalbumin immunization, levels of antigen specific IgG3 antibody are significantly lower
• an impaired IgG3 response is also observed after KLH immunization, with antigen specific antibodies being 1/10 of that found in wild-type
• IgG3 levels are lower than controls 100 days after infection with toxoplasma gondii
• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-15 in the same manner as wild-type CD8+ T cells
• the percentage of antigen-specific CD8+ T cells found in the spleen is a third lower than controls after vaccination
• the percentage of CD8+ T cells making IFN-gamma one week after vaccination is about half that of wild-type controls
• the cytotoxic activity of CD8+ T cells is significantly lower than wild-type cells
• IL-17 production by CD4 T cells is much lower than controls when activated with IL-6 and TGF-beta in vitro
• there is no IL-17 production from T cells when activated in vitro with IL-21 and TGF-beta compared to the robust production of controls

hematopoietic system
• serum levels of IgE in nave mice are higher than in controls
• ovalbumin immunized mice have variable total IgE levels with some mice having levels similar to wild-type and some mice having 3- to 6- fold higher amounts
• total IgE production is increased about 50-fold after KLH immunization with similar increases with antigen specific antibody
• IgE levels are 20- to 25- fold greater than controls 100 days after infection with toxoplasma gondii
• serum levels of IgG1 in nave mice are lower than in controls
• after immunization with ovalbumin, the normal increase in IgG1 seen in wild-type mice is markedly impaired in these mice
• in immunized mice, total serum IgG1 is 4 to 5% of wild-type and levels of antigen-specific antibody is 0.1% of that in wild-type
• an impaired IgG1 response is also observed after keyhole limpet hemocyanin (KLH) immunization, with antigen specific antibodies being 1/10 of that found in wild-type
• IgG1 levels are third of controls 100 days after infection with toxoplasma gondii
• IgG2a levels are lower than controls 100 days after infection with toxoplasma gondii
• serum levels of IgG2b in nave mice are lower than in controls
• after ovalbumin immunization, levels of antigen specific IgGb2 antibody are significantly lower
• an impaired IgG2b response is also observed after KLH immunization, with antigen specific antibodies being 1/10 of that found in wild-type
• IgG2b levels are lower than controls 100 days after infection with toxoplasma gondii
• after ovalbumin immunization, levels of antigen specific IgG3 antibody are significantly lower
• an impaired IgG3 response is also observed after KLH immunization, with antigen specific antibodies being 1/10 of that found in wild-type
• IgG3 levels are lower than controls 100 days after infection with toxoplasma gondii
• CD8+ T cell proliferation in vitro is not enhanced in the presence of IL-15 in the same manner as wild-type CD8+ T cells
• the percentage of antigen-specific CD8+ T cells found in the spleen is a third lower than controls after vaccination
• the percentage of CD8+ T cells making IFN-gamma one week after vaccination is about half that of wild-type controls
• the cytotoxic activity of CD8+ T cells is significantly lower than wild-type cells




Genotype
MGI:3814064
hm2
Allelic
Composition
Il21rtm1Wjl/Il21rtm1Wjl
Genetic
Background
NOD.Cg-Il21rtm1Wjl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Wjl mutation (6 available); any Il21r mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• T cells isolated from pancreatic lymph nodes have about 25% less proliferative response when activated in vitro

immune system
• T cells isolated from pancreatic lymph nodes have about 25% less proliferative response when activated in vitro
• about a third to a half less Th17 T cells are produced when CD4+ T cells isolated from either spleen or pancreatic lymph nodes are cultured under Th17-polarizing conditions
• CD4+ T cells produce half to three-quarter less IL-17 than controls when stimulated in vitro
• CD4+ T cells cultured under Th17-polarizing conditions also produce much less IL-17 than controls
• only 5% of mice develop diabetes (determined by blood glucose being greater than 250mg/dl) compared to 60% of NOD mice not carrying the mutant allele
• 12-week old mice lack inflammatory infiltration of the pancreas islet cells as is typically found in age-matched NOD controls

hematopoietic system
• T cells isolated from pancreatic lymph nodes have about 25% less proliferative response when activated in vitro
• about a third to a half less Th17 T cells are produced when CD4+ T cells isolated from either spleen or pancreatic lymph nodes are cultured under Th17-polarizing conditions




Genotype
MGI:3835838
cx3
Allelic
Composition
Il21rtm1Wjl/Il21rtm1Wjl
X/Yaa
Genetic
Background
BXSB.129(Cg)-Il21rtm1Wjl/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Wjl mutation (6 available); any Il21r mutation (25 available)
Yaa mutation (18 available); any Yaa mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

mortality/aging
N
• the hypergammaglobulinemia, autoantibody production, reduced frequencies of marginal zone B cells and monocytosis, renal disease, and premature morbidity that are found in Yaa bearing mice with at least one wildtype copy of the interleukin 21 receptor are ameliorated or prevented by the disruption of the interleukin 21 receptor (J:144484)
• unlike IL21R heterozygous B2M null controls, these double homozygotes do not develop the Lupus-like autoimmune syndrome caused by Yaa and generally survive beyond 40 weeks of age (J:179430)




Genotype
MGI:3813932
cx4
Allelic
Composition
Il21rtm1Wjl/Il21rtm1Wjl
Il4tm1Cgn/Il4tm1Cgn
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Wjl mutation (6 available); any Il21r mutation (25 available)
Il4tm1Cgn mutation (4 available); any Il4 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• serum levels of IgGA in nave mice are lower than in controls
• similar defects are noted upon immunization with keyhole limpet hemocyanin (KLH)
• serum levels of IgG1 in nave mice are several log units lower than in controls
• these mice have severely impaired production of antigen-specific IgG1 after immunization with trinitrophenyl-conjugated chicken gamma-globulin (TNP-CGG)
• similar defects are noted upon immunization with KLH
• serum levels of IgG2a in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2a after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• serum levels of IgG2b in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• serum levels of IgG3 in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG3 after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• these mice have 10 to 20% of normal production levels of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• lymph nodes after immunization have barely recognizable, poorly organized germinal center-like areas with scattered apoptotic cells

hematopoietic system
• serum levels of IgGA in nave mice are lower than in controls
• similar defects are noted upon immunization with keyhole limpet hemocyanin (KLH)
• serum levels of IgG1 in nave mice are several log units lower than in controls
• these mice have severely impaired production of antigen-specific IgG1 after immunization with trinitrophenyl-conjugated chicken gamma-globulin (TNP-CGG)
• similar defects are noted upon immunization with KLH
• serum levels of IgG2a in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2a after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• serum levels of IgG2b in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• serum levels of IgG3 in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG3 after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
• these mice have 10 to 20% of normal production levels of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH





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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory