Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkltm1Hkp mutation
(1 available);
any
Crkl mutation
(15 available)
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mortality/aging
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• Background Sensitivity: die during embryogenesis unlike on a Black Swiss background in which mutants are viable
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embryo
cardiovascular system
liver/biliary system
Allelic
Composition |
Crkltm1Hkp/Crkltm1Hkp
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * Black Swiss |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkltm1Hkp mutation
(1 available);
any
Crkl mutation
(15 available)
|
|
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mortality/aging
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• Background Sensitivity: mutants with decreased birth weight have an increased chance of dying within the first 4 days of life, however those that survive are viable and fertile unlike mutants on a 129/Sv background which die during embryogenesis
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growth/size/body
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• lower birth weight, however surviving mutants reach the same weight and size by 6 months of age
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cardiovascular system
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• some mutants have a small septum defect in the heart
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limbs/digits/tail
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• tail vertebra show an irregular, wedge-like shape and the lateral borders are fused to each other on one side, resulting in kinks
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• 53% of pups at birth have bent or curved tails
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skeleton
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• tail vertebra show an irregular, wedge-like shape and the lateral borders are fused to each other on one side, resulting in kinks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkltm1Hkp mutation
(1 available);
any
Crkl mutation
(15 available)
Tg(BCR/ABL)623Hkp mutation
(2 available)
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mortality/aging
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• average survival is 158 days
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neoplasm
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• develop B-lineage leukemia to the same extent as mice expressing the transgene alone
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• develop B-lineage lymphoma to the same extent as mice expressing the transgene alone
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Analysis Tools