Mouse Genome Informatics
hm1
    Slc27a4wrfr/Slc27a4wrfr
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Histological analysis of the Slc27a4wrfr/Slc27a4wrfr mouse

mortality/aging
• mice died several hours after birth

behavior/neurological
• mice failed to suckle
• body movements were extremely limited in mice

digestive/alimentary system
• herniated intestines observed in 10 % of mutant mice

respiratory system

integument
• hair growth is impaired; compared to controls, hair growth was sparse in skin taken from E18.5 mice and grafted onto nude
• few developing hair follicles
• skin appeared abnormally shiny at birth
• the skin mutant mice lacked the wrinkled appearance associated with normal perinatal mice
• in newborns, epidermis was 3 times thicker than littermate controls

Mouse Models of Human Disease
OMIM IDRef(s)
Restrictive Dermopathy, Lethal 275210 J:83282