Analysis Tools
immune system
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• mice have twice the serum levels as controls of antigen specific IgG1 after immunization with a T cell dependent antigen
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• the delayed-type hypersensitivity response is 2-fold greater than controls when mice are sensitized and then exposed to FITC
• the site of exposure is moderately thickened, with dense infiltrates of
neutrophils, lymphocytes, and macrophages, and contains intraepithelial
pustules and microabscesses
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• GM-CSF secretion by peritoneal macrophages in response to LPS+ IFN-gamma is reduced by more than a third compared to controls
• however, GM-CSF production is increased 2.5 fold by activated T cells compared to controls
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• IFN-gamma secretion by activated T cells is increased 5-fold compared to controls
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• IL-1beta secretion by peritoneal macrophages in response to LPS+ IFN-gamma is reduced by about a third compared to controls
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• IL-4 secretion by activated T cells is increased two-fold compared to controls
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• IL-6 secretion by peritoneal macrophages in response to LPS+ IFN-gamma is reduced by about a half compared to controls
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• the 50% lethal dose of LPS for mutant mice is 34.05 mg LPS/kg animal body weight compared to 18.15 mg LPS/kg animal body weight
• treatment with the highest dose of LPS, 2 mg/animal, resulted in a 20% survival of CCR5-deficient mice vs 0% survival of wild-type mice
• the second highest dose, 0.8 mg/animal, resulted in a 50% survival of mutant mice vs 17% of wild-type mice
• treatment with the lower doses, 0.4, 0.2, or 0.1 mg/animal, resulted in 78, 100, or 100% survival of mutant mice vs 50, 80, or100% survival of wild-type mice
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• Listera titers in the liver are 10-fold higher than controls 5 days after infection with L. monocytogenes
• titers in the lung and spleen are similar to wild-type
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hematopoietic system
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• mice have twice the serum levels as controls of antigen specific IgG1 after immunization with a T cell dependent antigen
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