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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cacnb2tm1Rgg
targeted mutation 1, Ronald G Gregg
MGI:2429694
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cacnb2tm1Rgg/Cacnb2tm1Rgg involves: 129S7/SvEvBrd MGI:3843805
hm2
Cacnb2tm1Rgg/Cacnb2tm1Rgg involves: 129S7/SvEvBrd * FVB MGI:3797409
cx3
Cacnb2tm1Rgg/Cacnb2tm1Rgg
Pde6brd1/Pde6brd1
Tg(Myh6-Cacnb2)1Rgg/0
involves: 129S7/SvEvBrd * C57BL/6J * FVB MGI:2451250


Genotype
MGI:3843805
hm1
Allelic
Composition
Cacnb2tm1Rgg/Cacnb2tm1Rgg
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1Rgg mutation (0 available); any Cacnb2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mice die during embryogenesis due to failure of cardiac contraction

cardiovascular system
• failure of cardiac contraction during embryogenesis




Genotype
MGI:3797409
hm2
Allelic
Composition
Cacnb2tm1Rgg/Cacnb2tm1Rgg
Genetic
Background
involves: 129S7/SvEvBrd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1Rgg mutation (0 available); any Cacnb2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice exhibit normal electroretinograms




Genotype
MGI:2451250
cx3
Allelic
Composition
Cacnb2tm1Rgg/Cacnb2tm1Rgg
Pde6brd1/Pde6brd1
Tg(Myh6-Cacnb2)1Rgg/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1Rgg mutation (0 available); any Cacnb2 mutation (6 available)
Pde6brd1 mutation (88 available); any Pde6b mutation (117 available)
Tg(Myh6-Cacnb2)1Rgg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• progressive loss of photoreceptor cell bodies
• increased apoptotic cell death at 21 days of age
• degeneration of photoreceptors occurs but is delayed at P16, P18, and P21 compared to homozygous Pde6b mutants
• progressive thinning of the outer nuclear layer
• the OPL appears disorganized
• the OPL appears thinner than wild-type and other controls
• mutant mice show decreased sensitivity to light
• the b-wave of mutant mice is reduced in amplitude at all flash intensities; the a-wave appears similar to controls
• cone ERGs of mutant mice are smaller in amplitude and negative in polarity

nervous system
• progressive loss of photoreceptor cell bodies
• increased apoptotic cell death at 21 days of age
• degeneration of photoreceptors occurs but is delayed at P16, P18, and P21 compared to homozygous Pde6b mutants





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory