Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1Rgg mutation
(0 available);
any
Cacnb2 mutation
(50 available)
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mortality/aging
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• homozygous mice die during embryogenesis due to failure of cardiac contraction
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cardiovascular system
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• failure of cardiac contraction during embryogenesis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1Rgg mutation
(0 available);
any
Cacnb2 mutation
(50 available)
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vision/eye
N |
• mice exhibit normal electroretinograms
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1Rgg mutation
(0 available);
any
Cacnb2 mutation
(50 available)
Pde6brd1 mutation
(41 available);
any
Pde6b mutation
(119 available)
Tg(Myh6-Cacnb2)1Rgg mutation
(0 available)
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vision/eye
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• progressive loss of photoreceptor cell bodies
• increased apoptotic cell death at 21 days of age
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• degeneration of photoreceptors occurs but is delayed at P16, P18, and P21 compared to homozygous Pde6b mutants
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• progressive thinning of the outer nuclear layer
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• the OPL appears disorganized
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• the OPL appears thinner than wild-type and other controls
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• mutant mice show decreased sensitivity to light
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• the b-wave of mutant mice is reduced in amplitude at all flash intensities; the a-wave appears similar to controls
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• cone ERGs of mutant mice are smaller in amplitude and negative in polarity
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nervous system
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• progressive loss of photoreceptor cell bodies
• increased apoptotic cell death at 21 days of age
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• degeneration of photoreceptors occurs but is delayed at P16, P18, and P21 compared to homozygous Pde6b mutants
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