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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd200tm1Jods
targeted mutation 1, Jonathon D Sedgwick
MGI:2429651
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd200tm1Jods/Cd200tm1Jods C57BL/6-Cd200tm1Jods MGI:3576859


Genotype
MGI:3576859
hm1
Allelic
Composition
Cd200tm1Jods/Cd200tm1Jods
Genetic
Background
C57BL/6-Cd200tm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd200tm1Jods mutation (0 available); any Cd200 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased numbers of CD11b cells in spleen (J:65982)
• all macrophage lineages increased (J:65982)
• 30% increase in resident retinal macrophage (J:79906)
• features of cell suggest activation
• changed from spherical to tubular formation
• slightly, especially in the mesenteries
• marginal zone macrophages of the spleen are activated
• lymph node macrophages are activated
• form aggregates normally associated with inflammation or neurodegeneration
• accelerated response to nerve damage (facial nerve transection)
• Th2 associated cytokines are increased in response to "recall" antigens
• accelerated development of experimental autoimmune encephalitis
• accelerated development of experimental autoimmune uveoretinitis
• increased susceptibility to collagen induced arthritis

nervous system
• features of cell suggest activation
• form aggregates normally associated with inflammation or neurodegeneration
• accelerated response to nerve damage (facial nerve transection)

cellular
• in "non-T cells" and macrophage

hematopoietic system
• increased numbers of CD11b cells in spleen (J:65982)
• all macrophage lineages increased (J:65982)
• 30% increase in resident retinal macrophage (J:79906)
• features of cell suggest activation
• marginal zone macrophages of the spleen are activated
• lymph node macrophages are activated
• form aggregates normally associated with inflammation or neurodegeneration
• accelerated response to nerve damage (facial nerve transection)

skeleton
• increased susceptibility to collagen induced arthritis

homeostasis/metabolism
• Th2 associated cytokines are increased in response to "recall" antigens

Mouse Models of Human Disease
OMIM ID Ref(s)
Autoimmune Disease 109100 J:65982





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory