Mouse Genome Informatics
hm1
    Cd200tm1Jods/Cd200tm1Jods
C57BL/6-Cd200tm1Jods
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased numbers of CD11b cells in spleen (J:65982)
• all macrophage lineages increased (J:65982)
• 30% increase in resident retinal macrophage (J:79906)
• features of cell suggest activation
• changed from spherical to tubular formation
• slightly, especially in the mesenteries
• marginal zone macrophages of the spleen are activated
• lymph node macrophages are activated
• form aggregates normally associated with inflammation or neurodegeneration
• accelerated response to nerve damage (facial nerve transection)
• Th2 associated cytokines are increased in response to "recall" antigens
• accelerated development of experimental autoimmune encephalitis
• accelerated development of experimental autoimmune uveoretinitis
• increased susceptibility to collagen induced arthritis

nervous system
• features of cell suggest activation
• accelerated response to nerve damage (facial nerve transection)
• form aggregates normally associated with inflammation or neurodegeneration

cellular
• in "non-T cells" and macrophage

hematopoietic system
• increased numbers of CD11b cells in spleen (J:65982)
• all macrophage lineages increased (J:65982)
• 30% increase in resident retinal macrophage (J:79906)
• features of cell suggest activation
• marginal zone macrophages of the spleen are activated
• lymph node macrophages are activated
• form aggregates normally associated with inflammation or neurodegeneration
• accelerated response to nerve damage (facial nerve transection)

skeleton
• increased susceptibility to collagen induced arthritis

homeostasis/metabolism
• Th2 associated cytokines are increased in response to "recall" antigens

Mouse Models of Human Disease
OMIM IDRef(s)
Autoimmune Disease 109100 J:65982